- J073E5 (See other available formats)
- Regulatory Status
- Other Names
- CC CKR3, MIP1-α receptor like-2, eotaxin receptor, MIP1-alpha receptor like-2
- Rat IgG2a, κ
- Ave. Rating
- Submit a Review
- Product Citations
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CD193, also known as CC-chemokine receptor 3 (CCR3), CC CKR3, MIP1-α receptor like-2, and eotaxin receptor, is a member of the G protein-coupled, seven transmembrane receptor family. It binds to the CC chemokines eotaxin, eotaxin-2, and eotaxin-3 with high affinity. CD193 has also been reported to bind RANTES, MCP-3, and MCP-4 with low affinity. CD193 is expressed on mouse eosinophils, basophils, mast cells, mononuclear phagocytes, platelets, hematopoietic progenitor cells, and keratinocytes. It is thought to play a role in allergic diseases such as bronchial asthma and allergic rhinitis. CD193 also function as a co-receptor for HIV-1 and HIV-2, and the binding of eotaxin with CD193 has been shown to inhibit HIV infection in some cell types.Product Details
- Verified Reactivity
- Antibody Type
- Host Species
- Mouse CCR3-transfectants
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 647 under optimal conditions.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.5 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
* Alexa Fluor® 647 has a maximum emission of 668 nm when it is excited at 633 nm / 635 nm.
Alexa Fluor® and Pacific Blue™ are trademarks of Life Technologies Corporation.
View full statement regarding label licenses
- Excitation Laser
Red Laser (633 nm)
- Product Citations
AB_2561535 (BioLegend Cat. No. 144507)
AB_2561536 (BioLegend Cat. No. 144508)
- G-protein coupled, seven transmembrane domain receptor, 356 amino acids
Eosinophils, basophils, mast, mononuclear phagocytes, platelets, hematopoietic progenitor, keratinocytes
- Co-receptor for HIV-1 and HIV-2, allergy
- Eotaxin, eotaxin-2, eotaxin-3, RANTES, MCP-3, and MCP-4
- Cell Type
- Basophils, Eosinophils, Hematopoietic stem and progenitors, Mast cells, Platelets
- Biology Area
- Cell Biology, Immunology, Innate Immunity, Signal Transduction
- Molecular Family
- CD Molecules, Cytokine/Chemokine Receptors, GPCR
- Antigen References
1. Zlotnik A, et al. 2006. Genome Biol. 7:243.
2. Kodali RB, et al. 2004. Arterioscler. Thromb. Vasc. Biol. 24:1211.
3. Das AM, et al. 2006. J. Pharmacol. Exp. Ther. 318:411.
4. Huaux F, et al. 2005. Am. J. Pathol. 167:1485.
5. Puxeddu I, et al. 2006. J. Allergy Clin. Immunol. 117:103.
- Gene ID
- 12771 View all products for this Gene ID
- View information about CD193 on UniProt.org
- Does staining at room temperature or even at 37°C help for checking chemokine receptors expression?
Due to continuous recycling of many chemokine receptors, it may be worthwhile to consider staining at room temperature or at 37°C if the staining at lower temperature (which can potentially reduce receptor turnover) is not optimal.
|PE anti-mouse CD193 (CCR3)||J073E5||FC|
|Alexa Fluor® 647 anti-mouse CD193 (CCR3)||J073E5||FC|
|FITC anti-mouse CD193 (CCR3)||J073E5||FC|
|APC anti-mouse CD193 (CCR3)||J073E5||FC|
|PE/Cyanine7 anti-mouse CD193 (CCR3)||J073E5||FC|
|Brilliant Violet 421™ anti-mouse CD193 (CCR3)||J073E5||FC|
|PerCP/Cyanine5.5 anti-mouse CD193 (CCR3)||J073E5||FC|
|Biotin anti-mouse CD193 (CCR3)||J073E5||FC|
|Purified anti-mouse CD193 (CCR3)||J073E5||FC|
|APC/Fire™ 750 anti-mouse CD193 (CCR3)||J073E5||FC|
|TotalSeq™-A0808 anti-mouse CD193 (CCR3)||J073E5||PG|
|TotalSeq™-C0808 anti-mouse CD193 (CCR3) Antibody||J073E5||PG|
|APC/Cyanine7 anti-mouse CD193 (CCR3)||J073E5||FC|
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Compare Data Across All Formats
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PE anti-mouse CD193 (CCR3)
Alexa Fluor® 647 anti-mouse CD193 (CCR3)
FITC anti-mouse CD193 (CCR3)
APC anti-mouse CD193 (CCR3)
PE/Cyanine7 anti-mouse CD193 (CCR3)
Brilliant Violet 421™ anti-mouse CD193 (CCR3)
PerCP/Cyanine5.5 anti-mouse CD193 (CCR3)
Biotin anti-mouse CD193 (CCR3)
Purified anti-mouse CD193 (CCR3)
APC/Fire™ 750 anti-mouse CD193 (CCR3)
TotalSeq™-A0808 anti-mouse CD193 (CCR3)
TotalSeq™-C0808 anti-mouse CD193 (CCR3) Antibody
APC/Cyanine7 anti-mouse CD193 (CCR3)