- AA10 (See other available formats)
- Other Names
- β-3 Tubulin, Neuronal class III beta-tubulin, β3-tub
- Mouse IgG2a, κ
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- Product Citations
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Tubulin is the main component of microtubules. In adults, tubulin beta 3 (TUBB3) is primarily expressed in neurons and is commonly used as a neuronal marker. It plays an important role in neuronal cell proliferation and differentiation. Mutations in this gene cause congenital fibrosis of the type 3 extraocular muscles. Tubulin beta 3 (TUBB3) is also found in a wide range of tumors. Studies indicate that it is a predictive and prognostic marker in various tumors.Product Details
- Mouse, Rat, Human
- Antibody Type
- Host Species
- Fusion protein
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 594 under optimal conditions. The solution is free of unconjugated Alexa Fluor® 594.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
ICC - Quality tested
IHC-F, IHC-P, 3-D IHC - Validated
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescence staining. For immunocytochemistry microscopy, a concentration range of 2.5 - 5.0 μg/ml is recommended. For immunohistochemical staining on frozen tissue sections, the suggested use is 0.6 - 5 µg/mL. For immunohistochemical staining on formalin-fixed paraffin-embedded tissue sections, the suggested use of this reagent is 5.0 - 10 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.
* Alexa Fluor® 594 has an excitation maximum of 590 nm, and a maximum emission of 617 nm.
Alexa Fluor® and Pacific Blue™ are trademarks of Life Technologies Corporation.
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AB_2565285 (BioLegend Cat. No. 657408)
- 450 amino acids with predicted molecular weight of 50 kD
- Plays important roles in neuronal cell proliferation and differentiation
- Alpha tubulin, kinesin and dynein
- Cell Type
- Mature Neurons
- Biology Area
- Cell Biology, Cell Cycle/DNA Replication, Cell Motility/Cytoskeleton/Structure, Immunology, Neuroscience, Neuroscience Cell Markers
- Molecular Family
- Antigen References
1. Katsetos CD, et al. 2003. J. Child Neurol. 18:851.
2. Mobarakeh ZT, et al. 2012. Cell Biol. Int. Rep. (2010) 19:e00015.
3. Locher H, et al. 2013. Differentiation. 85:173.
4. Karki R, et al. 2013. Expert Opin. Ther. Targets. 17:461.
5. Mariani M, et al. 2011. Curr. Mol. Med. 11:726.
6. Koh Y, et al. 2009. Ann. Oncol. 20:1414.
- Gene ID
- 10381 View all products for this Gene ID
- View information about Tubulin beta-3 on UniProt.org
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