Cellular Functions

Ubiquitination – Ubiquitin is a small regulatory protein that is attached to other proteins to control processes like degradation and endocytic trafficking. Ubiquitin accumulates in morphologically distinct proteinaceous deposits associated with neurodegeneration, and can therefore be used as a marker for disease.

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Autophagy – Autophagy is a process that degrades and removes dysfunctional proteins and damaged organelles by delivering cytoplasmic material to the lysosome. Since autophagy is responsible for clearing pathogenic protein aggregates, defects in autophagy pathways have been linked to neurodegenerative diseases.

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Synaptic function – Synapses are the junctions between neurons, and are the sites of neurotransmitter release and reception. Loss of synaptic function and connections during neurodegenerative diseases causes a breakdown of the nervous system and its ability to operate properly.

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