Type II cytokine (T2) receptors are similar in structure to type I cytokine receptors. However, they differ in the placement of a conserved cysteine sequence and T2 receptors do not possess the WSXWS amino acid motif. T2 receptors are known for mediating the function of Type I and II interferons and the interleukin-10 family. The functions of these receptors vary greatly. For example, interferon-γ is known for its potent inflammatory effects, while IL-10 is an immunosuppressive cytokine.

IL-10	IL-19/IL-20/IL-24	IL-22 Set 1	IL-22 Set 2
IL-20/IL-24 IL-26 IL-28A/IL-28B/IL-29