IL-1 Pathway

IL-1 is a pyrogen, originally discovered in connection with fever responses to pathogens. IL-1 is an activating factor for lymphocytes also known to damage joints and influence liver protein levels. IL-1 is made by several cell types, including macrophages, monocytes, dendritic cells, B cells, NK cells, and epithelial cells. IL-1 upregulates endothelial cell adhesion molecule expression and can affect the hypothalamus and cause an increase in body temperature. IL-1α and -β are produced in pro-forms that require proteolytic cleavage to create the shorter, active form. IL-1 binds to the cell surface type I and II IL-1 receptors (IL-1RI and IL-1RII). IL-1α and -β and IL-1RA can compete for binding to these receptors. However, only IL-1RI, not IL-1RII, is functional because IL-1RII lacks a cytoplasmic domain and is thus unable to transmit signals to downstream steps.

 

Click on the poster below to view the interactive version.

 

IL-1 Pathway

ProductsHere
Insert Note Here
Save Close Clear
Lab Timer
Tools
Login/Register
Forgot your password? Reset Password
Request an Account