Chemokine Receptor Structure
  • Seven transmembrane regions
  • Amino terminus (NH2) and extracellular loops contribute to the ligand specificity.
  • G-coupled proteins at the carboxy terminus (COOH) allow for downstream signaling.
SH Park et al. Nature 491, 779 (2012) doi:10.1038/nature11580
Three-dimensional structure of CXCR1.