Receptor Structure

Chemokine Receptor Structure

• Seven transmembrane regions
• Amino terminus (NH2) and extracellular loops contribute to the ligand specificity.
• G-coupled proteins at the carboxy terminus (COOH) allow for downstream signaling.

SH Park et al. Nature 491, 779 (2012) doi:10.1038/nature11580

Three-dimensional structure of CXCR1.