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Growth Regulation

Growth Regulation

 

The initiation of cell replication begins with extracellular signals. For human and animal cells, this is usually triggered by growth factors or cytokines/chemokines.

 

View growth factors or cytokines/chemokines.

 

When extracellular signals are received, signal transduction pathways are initiated by proteins like kinases and phosphatases.

 

View products for kinases/phosphatases that regulate the cell cycle.

 

Signaling pathways ultimately lead to the activation of transcription factors that regulate genes involved in the cell cycle.

 

View products for transcription factors involved in the cell cycle.

Cell cycle inhibition – Dysregulation of the cell cycle can result in uncontrolled proliferation of cells, which will cause tumor growth and cancer. p53 is a major tumor-suppressor that can induce arrest of the cell cycle at the G1 phase and cause apoptosis. Another critical inhibitor of the cell cycle is CDKN2A, which negatively regulates CDK4 and CDK6.

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