Genetic mutations and variants play an important role in increasing the risk of developing inherited forms of Alzheimer’s disease (AD). A recent study has highlighted the connection between three known genetic risk factors (TREM2, APOE and APOJ) linked to AD (Yeh et al., Neuron 2016). TREM2 is a transmembrane glycoprotein expressed on the surface of microglia, and acts as a sensor for a distinct set of lipoproteins and apolipoproteins. TREM2 was shown to interact with APOE and APOJ, which are apolipoproteins capable of binding to amyloid beta (Aβ). This interaction helps facilitate the uptake and degradation of Aβ by the microglia. Interestingly, TREM2 AD variants demonstrate reduced ability to bind Aβ-apolipoprotein complexes. These findings underscore the involvement of the innate immune cells such as microglia in the clearance of Aβ aggregates, and their dysfunction as a predisposing risk factor for developing late onset AD. BioLegend is proud to offer a variety of antibodies for detection of AD-related proteins including those that are known AD genetic risk factors.
The interplay between AD genetic risk factors and microglia. TREM2 acts as a sensor of apolipoprotein-Aβ complexes in the central nervous system (CNS). Through interaction with APOE and APOJ proteins, TREM2 facilitates the degradation of Aβ by the microglia.

Related Products

Description Clone Reactivity Applications Cat. No.
Purified anti-TREM-2 Antibody 6E9 Mouse FC, IP 824801
Purified anti-Apo J (Clusterin) Antibody Poly18133 Human ELISA, WB, IHC 813301
Purified anti-Apo E Antibody D6E10 Human ELISA, WB, IHC, IP 803301, 803303
Purified anti-Apo E4 Antibody 5A9 Human ELISA, IHC 811701
Purified anti-Apo E4 Antibody 5B5/ApoE4 Human ELISA, IHC 811601
Purified anti-Apo E Antibody E6D7 Mouse ELISA, WB, IHC, IP 803401, 803403
Purified anti-Apo-E Antibody 3B3C32 Mouse WB 674802

Featured Products

Antibodies for Neurotransmitter Receptor-Related Proteins
Recombinant Human Clusterin (carrier-free)
Recombinant Human APP770
Recombinant Human APP751
Purified anti-Apo-D Antibody
Anti-β-Amyloid, 1-16 Antibody
Alexa Fluor® 488 anti-β-Amyloid, 1-16 Antibody
*Any references to promotions on this page may not be valid at this time. View our promotions page for the most up-to-date promotions.
Insert Note Here
Save Close Clear
Lab Timer
Remember me
Forgot your password? Reset Password
Request an Account