Synaptic Vesicle Exocytosis
Synaptic vesicles (SV) are organelles responsible for neuronal communication by storing neurotransmitters at the presynaptic terminals of axons, and releasing them into the extracellular space within the synaptic cleft. The docking and membrane fusion of synaptic vesicles with the presynaptic membrane in neurons is mediated by SNARE proteins. Syntaxin 1, SNAP-25 and synaptobrevin 2 are the key SNARE proteins involved in SV exocytosis. Syntaxin-1 and SNAP-25 reside in the presynaptic plasma membrane while synaptobrevin 2 is anchored in the presynaptic vesicle membrane. Upon synaptic stimulation, these proteins form a ternary complex that promotes the fusion of the vesicle and the presynaptic plasma membrane to drive neurotransmitter release. BioLegend is proud to offer a variety of neuroscience-related products for your research needs.
Learn more about Synaptic Function

Synaptic Function Products

Description Clone Reactivity Cat. No.
Purified anti-SNAP-25 Antibody SMI 81 Mammalian 836304
Purified anti-SNAP-25 Antibody SP12 Human, Mouse, Rat, Pig, Cat 805001
Purified anti-Synaptobrevin Antibody SP11 Human, Pig, Cat 805101
Anti-Synaptobrevin (VAMP) Antibody SP10 Human, Rabbit, Rat, Mouse, Hamster, Bovine, Pig 837001
Purified anti-Syntaxin Antibody SP8 Human, Mouse, Rat, Pig 827001

Featured Products

Microscopy

Description
Purified anti-Neurofilament Marker (pan axonal, cocktail)
Purified anti-Neurofilament H & M (NF-H/NF-M), Phosphorylated Antibody
Purified anti-MAP2 Antibody
Purified anti-Tubulin β 3 (TUBB3) Antibody
Alexa Fluor® 488 anti-Tubulin β 3 (TUBB3) Antibody
Alexa Fluor® 594 anti-Tubulin Beta 3 (TUBB3) Antibody
Alexa Fluor® 647 anti-Tubulin Beta 3 (TUBB3) Antibody
Purified anti-Synaptotagmin-12 Antibody
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