|While microglia only make up 5-10% of the total brain cells, they carry out important functions by clearing cellular debris and pruning synapses in the central nervous system (CNS). They are also the only macrophage type found within the parenchyma. Non-parenchyma macrophage function is less clearly understood, but they include: perivascular, meningeal, and choroid plexus types. While non-parenchyma macrophages share marker overlap, microglia can be more easily identified by expression of TMEM119, P2RY12, and SALL1. And, unlike their non-parenchymal counterparts, microglia have low expression of CD45 and MHC II.
BioLegend provides purified and fluorophore-conjugated antibodies for microglia-specific markers, as well as MojoSort™ cell sorting kits for CX3CR1 and LEGENDplex™ kits for microglia cytokine analysis.
Adapted from Li, Q. and Barres, B.A. 2017. Nat. Rev. Immunol. (Epub Ahead of Print) Pubmed
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