It has recently become clear that inflammation is more than just a consequence of Parkinson’s disease – it may be the root source of neuronal loss. Whether inflammation causes or is a result of α-Synuclein accumulation, anti-inflammatory treatment could be an effective strategy for preventing neurodegeneration. Characterize the inflammatory mechanisms that underlie neuronal pathology with BioLegend’s solutions for Parkinson’s disease research.
Discover how various pathways of inflammation contribute to Parkinson’s disease using LEGENDplex™ panels that simultaneously quantify up to 13 biomarkers. Measure general inflammatory cytokines like TNF-α along with specific markers of neuronal damage like VILIP-1 in a single multiplex assay.
 
 
α-Synuclein is expressed principally in the central nervous system (CNS), but is also found at low concentrations in a variety of tissues. Unravel immune-neural relationships by pairing your inflammation data with measurements of α-Synuclein concentrations from our LEGEND MAX™ α-Synuclein ELISA Kit – which was developed in collaboration with the Michael J. Fox Foundation, and has a 5-star quality review. Learn how it was used in a recent study to characterize cerebrospinal fluid samples from the Parkinson’s Progression Markers Initiative. Standard curve showing sensitivity of the LEGEND MAX™ α-Synuclein ELISA Kit

Primary mouse astrocytes stained for IHC with anti-GFAP (SMI-25) Alexa Fluor® 488 (green), purified anti-VDAC1 (N152B/23) with an Alexa Fluor® 594 secondary antibody (red), and DAPI (blue).
Astrocytes and microglia are abundant non-neuron cells in the CNS that play important roles in Parkinson’s disease. Astrocytes in diseased brain tissue harbor α-Synuclein inclusions, and microglia secrete pro-inflammatory molecules that contribute to neurodegeneration. Isolation and characterization of these cell types from brain tissues can be challenging – learn how with our detailed technical protocols for astrocyte and microglia research.
 
 
Our neurodegeneration poster summarizes key pathways of neuronal disease, like protein aggregation and neuroinflammation. In addition to being a handy resource, it provides excellent décor for your lab or office. Request a copy or download here.
 
 
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