At each and every step of your workflow, we want to be able to disrupt and dismantle SARS-CoV-2. This means understanding its entry points into host cells and the pathways it utilizes. It means discerning effective cellular responses in COVID-19 patients and disease models. And it means discovering new biomarkers and pathways for therapeutic treatments, vaccine candidates, and viral detection kits. We've organized our diverse products (antibodies, recombinant proteins, cytokine detection kits, and proteogenomics profiling options) by workflow stages, making it easier to pick your reagents and start your experiments. In addition, we offer a blog and video library with informative content on COVID-19.


 

BioLegend wants to help in your fight against COVID-19

 

As noted on our COVID-19 Statement Webpage, BioLegend is here to collaborate with your organization to help you accelerate the development of diagnostic tests, therapeutics, and vaccines for SARS-CoV-2. Please reach out if you require a custom reagent or would like to tell us how we can support your work. Together, we can find a solution. 

 

SARS-CoV-2 Workflow

Click on a section in the image to scroll down to your area of interest.

 

Covid Workflowviral recognition Cellular Response biomarker

 


Viral Recognition and Inflammation

 

Viral entry and the resulting inflammation are key mechanisms under investigation by SARS-CoV-2 researchers. We provide SARS-CoV-2 recombinant proteins and antibodies to investigate the interactions between S1 spike protein and human ACE2 for viral entry. Our ELISA kits and LEGENDplex™ assays can further characterize early inflammation and the efficacy of interventions by tracking the cytokine response. By fully understanding the virus’ starting point and its subsequent effects on the body, we can dismantle SARS-CoV-2 before it has a chance to even start.

 

 

Cellular Responses and Anti-Viral Pathways

 

Monitor Cellular ResponseOnce you’ve studied the entry points and how SARS-CoV-2 attacks cells, you’re ready to shift your focus onto the immune cell response. In order to gauge an effective immune response, it is critical to characterize the cellular immune response, particularly T cells. We have developed unique tools: MojoSort™ kits for the isolation of desired populations; MHC monomers pre-loaded with SARS-CoV-2 peptides for antigen-specific T cell studies; and antibodies to detect key components of anti-viral pathways. BioLegend provides key tools for discovering how cells work together to dismantle
SARS-CoV-2.

 

Our new SARS-CoV-2-specific Flex-T™ MHC reagents simplify your protocol and save time. Each HLA monomer comes ready-to-use with fixed relevant SARS-CoV-2 peptides, removing the need for a peptide exchange step and allowing you to track T cells for potential vaccine candidates. Learn more with our Flex-T™ webpage.

 

Flex-T Diagram

 

 

MojoSort™ Kits allow you to use magnetic nanoparticles to quickly isolate cells of interest with high purity and yield. Based on our testing, cells isolated with MojoSort™ reagents retain functionality for downstream applications. Find kits for T cells, B cells, NK cells, and Monocytes

Recombinant Cytokines and Growth Factors are critical for eliciting cellular responses, including proliferation, differentiation, and cytokine production. Explore our recombinant proteins, which include many key cytokines in the host cell response to SARS-CoV-2. 

 

We offer many antibodies to detect important mediators involved in anti-viral pathways, including Toll-like receptors, STATs, NF-κB, and interferon regulatory factors. Our anti-viral pathway reagents have been validated in applications like western blotting, flow cytometry, functional assays, ChIP, and microscopy.

 

Featured Products

Chloroquine phosphate

Hydroxychloroquine sulfate

Beta-Catenin

CD44

E-Cadherin

Ezrin

IKK/NF-κB

Inflammasome

IRFs

MMPs

STATs

TLRs

 

Our comprehensive flow cytometry portfolio will help characterize any cell type, including those relevant to study anti-viral and SARS-CoV-2 immune responses. For those looking to detect various classes of human immunoglobulins, we also offer a selection of anti-human secondary reagents, which could be used to detect virus specific antibodies.

 


Biomarker Discovery and Monitoring

 

Biomarker Discovery and Monitoring

Deciphering the existence of yet undiscovered biomarkers can open the door to effective therapies and treatments. We have designed potent solutions in the research field to quickly identify novel biomarkers and immune pathways. Explore cell states and decipher genetic versus protein dynamics with our oligo-conjugates, TotalSeq™ antibodies. We also offer LEGENDScreen™ kits useful for screening hundreds of markers on cells via flow cytometry. These unique tools provide unprecedented cell characterization for biomarker discovery, leading to potential therapeutic treatment development.

 

TotalSeq™ Reagents for Proteogenomics can be used to characterize single cells in a high throughput manner. These antibody-oligo conjugates contain unique nucleotide barcodes that integrate seamlessly into existing workflows, enabling you to simultaneously analyze protein and RNA expression on a single cell level. TotalSeq™ is available as individual or pre-titrated, lyophilized antibody cocktails, or hashtags for multiplexing samples. Specifically, they can be used to enable:

 

 

  • Multiomic analysis (Protein + RNA) of immune cells and lung alveolar lavage in COVID-19 patients (TotalSeq™-A or B in combination with 10x Genomics Single Cell Expression Solution (3’ assay)).
  • TCR/BCR repertoire profiling in COVID-19 patients for immunotherapy and vaccine development (TotalSeq™-C with 10x Genomics Immune Profiling Solution (5’ assay)).

 

LEGENDScreen™ kits offer a rapid screening method for cellular samples. Kits include several 96-well plates with each well containing a different lyophilized PE-conjugated antibody useful for staining cells. Our human kit contains antibodies for 361 cell surface markers and 10 isotype controls). Our mouse kit contains 255 antibodies for cell surface markers and 11 isotype controls. View our LEGENDScreen™ products.

 


BioLegend wants to help in your fight against COVID-19
 

BioLegend is ready to collaborate with your organization to help you accelerate the development of diagnostic tests, therapeutics, and vaccines for SARS-CoV-2, and be a partner in your research. Please tell us how we can support your work.

 

Your personal data will be handled according to our Privacy Policy. In addition, if you are located within a Distributor Territory, you may be contacted directly by them. We never sell your data to anyone. To view, edit or delete your preferences or personal information, please fill out our Privacy Request Form.

 

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