- O91G6 (See other available formats)
- Other Names
- Cytochrome b-c1 complex subunit 1, mitochondrial, Complex III subunit 1, Core protein I, Ubiquinol-cytochrome-c reductase complex core protein 1
- Mouse IgG1, κ
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- Product Citations
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The ubiquinol-cytochrome c reductase complex, also called mitochondrial complex III, is the third complex in the mitochondrial electron transport chain. The complex III is composed of 11 subunits that form a multi-segment transmembrane protein. It is part of the mitochondrial respiratory chain and plays essential roles in the synthesis of ATP. UQCRC1 may mediate formation of the complex between cytochromes c and c1.
The dysregulated UQCRC1 is involved in impaired mitochondrial electron transport chain function and was found in clear cell renal cell carcinoma and Alzheimer's disease.Product Details
- Antibody Type
- Host Species
- Human recombinant protein fragment corresponding to amino acids 46-305 of human UQCRC1 expressed in E. Coli.
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
WB - Quality tested
KO/KD-WB, ICC - Verified
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.1 - 1.0 µg per ml. For immunocytochemistry, a concentration range of 0.5 - 5.0 μg/ml is recommended. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
This clone has very weak cross-reactivity with mouse UQCRC1.
Antibody specificity confirmed by partial knock-down of the target using siRNA (in-house tested).
AB_2687203 (BioLegend Cat. No. 697601)
AB_2687187 (BioLegend Cat. No. 697602)
- 480 amino acids, and predicted Mw is 52.6kDa.
Mitochondrion inner membrane
- Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain.
- The bc1 complex contains 11 subunits: 3 respiratory subunits (cytochrome b, cytochrome c1 and Rieske/UQCRFS1), 2 core proteins (UQCRC1/QCR1 and UQCRC2/QCR2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10
- Biology Area
- Cell Biology, Mitochondrial Function, Neuroscience, Neuroscience Cell Markers, Protein Synthesis
- Molecular Family
- Mitochondrial Markers
- Antigen References
1. Ellinger J, et al. 2016, Oncotarget 7: 86490.
2. Ma SL, et al. 2016, J. Psychiatr. Res. 76:143
- Gene ID
- 7384 View all products for this Gene ID
- View information about UQCRC1 on UniProt.org
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