- 129C1 (See other available formats)
- Regulatory Status
- Other Names
- BST2, tetherin, HM1.2 antigen, bone marrow stromal antigen 2, PDCA-1
- Rat IgG2b, κ
- Ave. Rating
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- Product Citations
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CD317, known as BST2, tetherin, HM1.2 antigen, bone marrow stromal antigen 2, or PDCA-1, is type II transmembrane glycoprotein with a molecular mass of 29-33 kD. It is predominantly expressed on Type I IFN-producing cells (IPCs) in naïve mice, but is up-regulated on most cell types following stimulation with type I IFNs and IFN-gamma. It is highly expressed on terminally differentiated normal plasmacytoid dendritic cells and some tumor cells, such as multiple myeloma, renal cell carcinoma, and melanoma cells. BST2 is a recently identified as IFN-induced cellular response factor that blocks release of HIV-1 and other retroviruses from infected cells. BST2 has been found to be the natural ligand of ILT7 in human model.Product Details
- Antibody Type
- Host Species
- Mouse plasmacytoid dendritic cells (DCs)
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
FC - Quality tested
IP - Reported in the literature, not verified in house
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per 106 cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Application References
- Blasius AL, et al. 2006. J. Immunol. 177:3260
- Cocka LJ, et al. 2012. PLoS Pathog. 8:e1002931. PubMed.
- Product Citations
AB_1953279 (BioLegend Cat. No. 127102)
- Type II transmembrane glycoprotein with a molecular mass of 29-33 kD.
- Expressed on type I IFN-producing cells, plasmacytoid dendritic cells, and neoplastic B cells, such as multiple myeloma.
- Recently identified as antiviral protein that blocks the release of nascent retrovirus or other particles from infected cells.
- Cell Type
- Dendritic cells, B cells
- Biology Area
- Immunology, Innate Immunity, Costimulatory Molecules
- Molecular Family
- CD Molecules
- Antigen References
1. Douglas JL. et al. 2009. J Virol. 83(16):7931
2. Cao W et al. 2009. J. Exp. Med. 206(7):1603
3. Neil SJ. et al. 2008. Nature 451:425
- Gene ID
- 69550 View all products for this Gene ID
- View information about CD317 on UniProt.org
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