- 13H3A44 (See other available formats)
- Other Names
- Interferon regulatory factor 1 (IRF-1)
- Mouse IgG2a, κ
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- Product Citations
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IRF1 is the first identified member of the interferon regulatory transcription factor family. Its expression is induced in response to pathogen infection or the stimulation of several cytokines, including type I and II IFN, IL-1, IL-6, and TNF-α. Upon stimulation, IRF1 is transcriptionally activated by STAT1 and NFκB transcription factors via the GAS (interferon-gamma-activated sequence) element in the IRF1 promoter. IRF1 plays important roles in mediating immune response during infection and development of T cells and NK cells. In addition to the immunomodulatory functions, IRF1 has also shown to be involved in the regulation of cell cycle progression, tumor suppression, and apoptosis. IRF1-mediated transcription can be repressed by IRF2 through competing for the same binding region on the promoters.Product Details
- Human, mouse
- Antibody Type
- Host Species
- Partial human IRF1 recombinant protein (147-325 a.a.)
- This antibody is provided in phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Affinity purified.
- 0.5 mg/mL
- Storage & Handling
- Upon receipt, store undiluted at 4°C.
WB - Quality tested
ICC, IP - Verified
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.5 - 2.0 µg per mL. For immunoprecipitation, the suggested use of this reagent is 2.0 - 10 μg per mL. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
Clone 13H3A44 does not cross-react with mouse.
- Product Citations
AB_2562631 (BioLegend Cat. No. 657602)
- 325 amino acids, predicted Mw is 37 kD and observed MW is 45kD. Contains an IRF tryptophan pentad repeat responsible for DNA binding.
- IRF1 is a transcription factor, regulating expression of IFN and IFN-inducible genes. It is also involved in regulating cell proliferation, apoptosis, tumor suppression, and various immune responses.
- Forms homodimers. Interacts with p300, MyD88, and PIAS3.
- Biology Area
- Apoptosis/Tumor Suppressors/Cell Death, Cell Biology, Cell Cycle/DNA Replication, Immunology, Innate Immunity, Transcription Factors
- Antigen References
1. Yang W, et al. 2012. PLoS One 7:e50932.
2. Schwartz JL, et al. 2011. Int. J. Breast Cancer. 2011:912102.
3. Horiuchi M, et al. 2011. J. Neuroinflammation. 8:8.
4. Frontini M, et al. 2009. Nucleic Acids Res. 37:1073.
5. Yarilina A, et al. 2008. Nat. Immunol. 9:378.
6. Kano S, et al. 2008. Nat. Immunol. 9:34.
- Gene ID
- 3659 View all products for this Gene ID
- View information about IRF1 on UniProt.org
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