Purified anti-human TCR Vβ5 Antibody

Pricing & Availability
Clone
MH3-2 (See other available formats)
Regulatory Status
RUO
Other Names
T cell receptor V beta 5
Isotype
Mouse IgG2a, κ
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Product Citations
publications
MH3-2_AF647_072110
Human peripheral blood lymphocytes stained with purified MH3-2 conjugated with Alexa Fluor® 647 and CD3 PE
  • MH3-2_AF647_072110
    Human peripheral blood lymphocytes stained with purified MH3-2 conjugated with Alexa Fluor® 647 and CD3 PE
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349301 25 µg 72.00€
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Description

Vβ5 T cell receptor (TCR Vβ5) is a variant of the TCR β chain which is heterodimerized with TCR α chain and expressed on a subset of αβ+ T cells. TCR α/β recognizes peptides presented by the MHC molecules and initiates T cell mediated immune responses. Patients with multiple sclerosis present an expansion of Vβ5.2+/5.3+ autoreactive T cells.

Product Details
Technical Data Sheet (pdf)

Product Details

Reactivity
Human, Cross-Reactivity: Macaque
Antibody Type
Monoclonal
Host Species
Mouse
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤2.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Application References
  1. Labrecque N, et al. 1993. J. Exp. Med. 177:1735. (FC)
  2. Oh S, et al. 2004. Cancer Res. 64:2610. (FC)
  3. Wilson JDK, et al. 1998. Eur. J. Immunol. 28:1172. (FC)
  4. Patel MR, et al. 2010. Cancer Res. 70:10141. PubMed
  5. Han JA, et al. 2014. Nanomedicine. 10:561. PubMed
Product Citations
  1. Patel M, et al. 2010. Cancer Res. 70:10141. PubMed
  2. Han J, et al. 2014. Nanomedicine. 10:561. PubMed
RRID
AB_10643416 (BioLegend Cat. No. 349301)

Antigen Details

Structure
Immunoglobulin superfamily, associates with TCR Vα chain and CD3 complex
Distribution
Subset of TCR αβ+ T cells
Function
Recognition of peptides presented by MHC molecules, responsible for T cell mediated immune response
Ligand/Receptor
MHC-peptide complex
Cell Type
T cells
Biology Area
Immunology, Adaptive Immunity
Molecular Family
TCRs
Antigen References

1. Kuchroo VK, et al. 2002. Annu. Rev. Immunol. 20:101.
2. Venturi V, et al. 2008. Nat. Rev. Immunol. 8:231.
3. Matsumoto Y, et al. 2003. J. Immunol. 170:4846.
4. Killestein J, et al. 2002. Ann. Neurol. 51:467.

Gene ID
6957 View all products for this Gene ID
UniProt
View information about TCR V beta5 on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 1    Revision Date: 01/22/2014

For research use only. Not for diagnostic use. Not for resale. BioLegend will not be held responsible for patent infringement or other violations that may occur with the use of our products.

 

*These products may be covered by one or more Limited Use Label Licenses (see the BioLegend Catalog or our website, www.biolegend.com/ordering#license). BioLegend products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products, reverse engineer functionally similar materials, or to provide a service to third parties without written approval of BioLegend. By use of these products you accept the terms and conditions of all applicable Limited Use Label Licenses. Unless otherwise indicated, these products are for research use only and are not intended for human or animal diagnostic, therapeutic or commercial use.

 

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Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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