- HLT2736 (See other available formats)
- Regulatory Status
- Other Names
- p19p40, JKA3 induced upon T cell activation
- Mouse IgG1, κ
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- Product Citations
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The HLT2736 clone recognizes human IL-23, a heterodimeric cytokine composed of the p40 subunit shared with IL-12 and a specific p19 subunit. This antibody recognizes heterodimeric IL-23, but does not react with the p40 subunit alone or recombinant IL-12(p70) when used as a capture antibody in ELISA. IL-23 is secreted by activated dendritic cells and macrophages and has been shown to enhance IFN-γ secretion by memory (CD45RO) T cells in an IL-2 dependent manner. IL-23 may also induce unique Th subset (designated ThIL-17) that secretes the cytokines IL-17, IL-6, TNF and low levels of IFN-γ. IL-23 has been shown to promote immunity to mycobacteria and has been shown to be upregulated in response to some viral infections and in psoriatic lesions. IL-23 binds to the IL-23 receptor comprised of a β1 subunit shared with the IL-12 receptor and IL-23-specific subunit. This antibody has been shown to be useful for Western blotting and immunohistochemistry using formalin-fixed, paraffin embedded tissues with (catalyzed signal amplification).Product Details
- Antibody Type
- Host Species
- Human recombinant p40 and p19 with elastin linker
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
WB - Quality tested
IHC-P - Reported in the literature, not verified in house
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting applications, a concentration range of 0.5 µg/ml is recommended. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
The purified HLT2736 antibody has been shown to be useful for Western blotting and immunohistochemistry using formalin-fixed, paraffin embedded tissues (with catalyzed signal amplification). This antibody weakly stains frozen sections. This clone does not cross-react with mouse.
- Application References
- Product Citations
AB_416323 (BioLegend Cat. No. 511201)
AB_416324 (BioLegend Cat. No. 511202)
- Member of the IL-12 cytokine family, heterodimeric cytokine composed of p40 subunit shared with IL-12 and a specific p19 subunit
Secreted by activated dendritic cells and macrophages
- Enhances IFN-γ secretion by memory (CD45RO) T cells in an IL-2 dependent manner; may induce unique Th subset (designated ThIL-17) secreting IL-17, IL-6, TNF and low levels of IFN-γ in EAE model; shown to promote immunity to mycobac
- IL-23 receptor (β1 subunit of IL-12 receptor and IL-23-specific subunit)
- Cell Type
- Dendritic cells, Macrophages
- Biology Area
- Molecular Family
- Antigen References
1. Parham C, et al. 2002. J. Immunol. 168:5699.
2. Verreck FA, et al. 2004. Proc. Natl. Acad. Sci. USA 101:4560.
3. Lee E, et al. 2004. J. Exp. Med. 199:125.
4. Oppmann B, et al. 2000. Immunity 13:715.
- Upregulated in viral infections such as HSV, increased in psoriatic lesions in monocytes and mature dendritic cells
- Gene ID
- 51561 View all products for this Gene ID
- View information about IL-23 p19 on UniProt.org
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