Purified anti-human CD49b Antibody

Pricing & Availability
P1E6-C5 (See other available formats)
Regulatory Status
Other Names
α2 integrin, VLA-2 α chain, Integrin α2 chain
Mouse IgG1, κ
Ave. Rating
Submit a Review
Product Citations
Human peripheral blood platelets stained with purified CD49b (clone P1E6-C5) or purified mouse IgG1, κ isotype control, followed by anti-mouse IgG PE.
  • P1E6-C5_Purified_CD49b_Antibody_FC_102813
    Human peripheral blood platelets stained with purified CD49b (clone P1E6-C5) or purified mouse IgG1, κ isotype control, followed by anti-mouse IgG PE.
Compare all formats
Cat # Size Price Quantity Check Availability Save
359301 50 µg 76€
Check Availability

Need larger quantities of this item?
Request Bulk Quote
359302 500 µg 287€
Check Availability

Need larger quantities of this item?
Request Bulk Quote

CD49b is a 170 kD transmembrane protein, also known as α2 integrin, VLA-2 α chain, Integrin α2 and GPIa. It associates with CD29 (β1 integrin) to form VLA-2, a collagen and laminin receptor on many cell types including monocytes, platelets, activated T cells, megakaryocytes, neuronal cells, epithelial cells, and osteoclasts. CD49b has been reported to interact with F-actin and matrix metalloproteinase 1. CD49b is a platelet alloantigen and has been associated with neonatal alloimmune thrombocytopenia. Deficiencies in this protein have been associated with hemorrhagic disorders.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Antibody Type
Host Species
HT1080 cells
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
The antibody was purified by affinity chromatography.
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.

FC - Quality tested
IP, ELISA - Reported in the literature, not verified in house

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.5 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Application Notes

Additional reported applications (for the relevant formats of this clone) include: in vitro blocking activity1,2, immunoprecipitation3, and ELISA4

Application References
  1. Hirsch MS, et al. 1997. Dev. Dyn. 210:249. (Block)
  2. Sawhney RS, et al. 2006. J. Biol. Chem. 281:8497. (Block)
  3. Lee SA, et al. 2009. Carcinogensis. 30:1872. (IP)
  4. Zßrate S, et al. 2004. J. Virol. 78:10839. (ELISA)
Product Citations
  1. Watanabe K, et al. 2018. Am J Physiol Cell Physiol. 315:C398. PubMed
AB_2562681 (BioLegend Cat. No. 359301)
AB_2562682 (BioLegend Cat. No. 359302)

Antigen Details

Integrin alpha chain family, type I membrane protein, alpha chain of heterodimeric integrin receptor, 170 kD; associates with CD29 to form collagen, laminin receptor

Broadly expressed on many cell types including B cells, monocytes, platelets, megakaryocytes, neuronal cells, epithelial cells, and osteoclasts

With CD29; binds collagen and laminin
Forms heterodimer with integrin β1 (CD29) which is a receptor for laminin and collagen
Biology Area
Immunology, Innate Immunity
Molecular Family
Adhesion Molecules, CD Molecules
Antigen References

1. Kaplan C, et al. 1991. Br. J. Haematol. 78:425.
2. Kiefel V, et al. 1991. Vox Sang. 60:244.
3. Nieuwenhuis HK, et al. 1985. Nature 318:470.
4. Takada Y and Helmer ME. 1989. J. Cell Biol. 109:397.

Gene ID
3673 View all products for this Gene ID
View information about CD49b on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 2    Revision Date: 11/25/2019

For research use only. Not for diagnostic use. Not for resale. BioLegend will not be held responsible for patent infringement or other violations that may occur with the use of our products.


*These products may be covered by one or more Limited Use Label Licenses (see the BioLegend Catalog or our website, www.biolegend.com/ordering#license). BioLegend products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products, reverse engineer functionally similar materials, or to provide a service to third parties without written approval of BioLegend. By use of these products you accept the terms and conditions of all applicable Limited Use Label Licenses. Unless otherwise indicated, these products are for research use only and are not intended for human or animal diagnostic, therapeutic or commercial use.


BioLegend Inc., 8999 BioLegend Way, San Diego, CA 92121 www.biolegend.com
Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

  • Purified anti-human CD49b

  • FITC anti-human CD49b

  • PE anti-human CD49b

  • APC anti-human CD49b

  • TotalSeq™-A0371 anti-human CD49b

  • PerCP/Cyanine5.5 anti-human CD49b

  • PE/Cyanine7 anti-human CD49b

  • TotalSeq™-C0371 anti-human CD49b

  • TotalSeq™-B0371 anti-human CD49b


Login / Register
Remember me
Forgot your password? Reset password?
Create an Account