- 2M2 (See other available formats)
- Regulatory Status
- Other Names
- β2M, β2-M, beta2-microglobulin b2-M, b2M
- Mouse IgG1, κ
- Ave. Rating
- Submit a Review
- Product Citations
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β2-microglobulin (β2M) is a 12 kD nonpolymorphic Ig like protein. It is a non-membrane-anchored glycoprotein and is noncovalently associated with 39-44 kD polymorphic heavy chains of MHC class I molecules to form HLA class I antigen complex. In association with HLA class I, β2M is expressed on all leukocytes, platelets, endothelial cells, and epithelial cells. β2M plays an essential role both in governing MHC class I molecules stability and in promoting antigen binding and presenting the antigen to CD3/TCR complex of CD8+ T cells.Product Details
- Human, African Green, Baboon, Cynomolgus, Rhesus, Swine (Pig, Porcine)
- Antibody Type
- Host Species
- Purified human β2-microglobulin
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
FC - Quality tested
WB, ELISA - Reported in the literature, not verified in house
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤2.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
Additional reported applications (for the relevant formats) include: Western blotting, and ELISA.
- Application References
- Product Citations
AB_492835 (BioLegend Cat. No. 316302)
- Nonpolymorphic Ig like structure, noncovalently associated with heavy chain of MHC class I molecules, 12 kD
Leukocytes, platelets, endothelial cells, epithelial cells
- Govern MHC class I molecule stability, promote MHC class I molecules binding and presenting peptide antigens to CD8+ T cells
- CD3/TCR complex, CD8
- Cell Type
- Leukocytes, Platelets, Endothelial cells, Epithelial cells
- Biology Area
- Molecular Family
- MHC Antigens
- Antigen References
1. Engelhard VH. 1994. Curr. Opin. Immunol. 6:13.
2. Williams DB, et al. 1989. J. Immunol. 142:2796.
3. Danliczyk UG and TL. Delovitch. 1994. J. Immunol. 153:3533.
4. Williams A, et al. 2002. Tissue Antigens 59:3.
- Gene ID
- 567 View all products for this Gene ID
- View information about beta2-microglobulin on UniProt.org
|Purified anti-human β2-microglobulin||2M2||FC, WB, ELISA|
|FITC anti-human β2-microglobulin||2M2||FC|
|PE anti-human β2-microglobulin||2M2||FC|
|Biotin anti-human β2-microglobulin||2M2||FC|
|APC anti-human β2-microglobulin||2M2||FC|
|HRP anti-human β2-microglobulin||2M2||ELISA Detection, FC|
|PE/Cyanine7 anti-human β2-microglobulin||2M2||FC|
|APC/Fire™ 750 anti-human β2-microglobulin||2M2||FC|
|PerCP/Cyanine5.5 anti-human β2-microglobulin||2M2||FC|
|PE/Dazzle™ 594 anti-human β2-microglobulin||2M2||FC|
|TotalSeq™-A0057 anti-human β2-microglobulin||2M2||PG|
|TotalSeq™-C0057 anti-human β2-microglobulin||2M2||PG|
|TotalSeq™-B0057 anti-human β2-microglobulin||2M2||PG|
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Purified anti-human β2-microglobulin
FITC anti-human β2-microglobulin
PE anti-human β2-microglobulin
Biotin anti-human β2-microglobulin
APC anti-human β2-microglobulin
HRP anti-human β2-microglobulin
PE/Cyanine7 anti-human β2-microglobulin
APC/Fire™ 750 anti-human β2-microglobulin
PerCP/Cyanine5.5 anti-human β2-microglobulin
PE/Dazzle™ 594 anti-human β2-microglobulin
TotalSeq™-A0057 anti-human β2-microglobulin
TotalSeq™-C0057 anti-human β2-microglobulin
TotalSeq™-B0057 anti-human β2-microglobulin