- W18139A (See other available formats)
- Other Names
- EML4, Echinoderm microtubule-associated protein-like 4
- Rat IgG2b, κ
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- Product Citations
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Echinoderm microtubule-associated protein-like 4 or EML4 plays a central role in the modification of microtubule structural dynamics and morphology. During mitosis, EML4 expression is upregulated and is associated with spindle formation. In lung cancer cells, a translocation mutation is associated with the EML4 gene, where parts of the gene fuses with the anaplastic lymphoma receptor tyrosine kinase (ALK) gene and generates an EML4-ALK fusion protein.Product Details
- Antibody Type
- Host Species
- Partial recombinant human EML4 protein.
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
- The antibody was purified by affinity chromatography.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
WB - Quality tested
ICC - Validated
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.05 - 1.0 µg/mL. For immunocytochemistry, a concentration of 1.0 μg/mL is recommended. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
This clone has not been tested for IP.
AB_2814524 (BioLegend Cat. No. 670801)
AB_2814525 (BioLegend Cat. No. 670802)
- EML4 is a 981 amino acid protein with a predicted molecular weight of 109 kD
- Microtubule formation
- Antigen References
- Yoshida A, et al. 2011. J Thorac Oncol. 10:1677-86.
- Soda M, et al. 2007. Nature. 448:561.
- Pollmann M, et al. 2006. Exp Cell Res. (17):3241-51.
- Gene ID
- 27436 View all products for this Gene ID
- View information about EML4 on UniProt.org
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