Purified anti-CD49b (Integrin α2) Antibody (Previously Covance catalog# MMS-488P)

Pricing & Availability
Clone
P1E6 (See other available formats)
Regulatory Status
RUO
Other Names
ITGA2, collagen receptor, VLA-2 subunit alpha, platelet antigen Br, platelet glycoprotein Ia, platelet glycoprotein GPIa, CD49 antigen-like family member B, platelet membrane glycoprotein Ia, very late activation protein 2 receptor, alpha-2 sub
Previously
Covance Catalog# MMS-488P
Isotype
Mouse IgG1
Ave. Rating
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Product Citations
publications
P1E6_Purified_Integrina2b1_Antibody_IHC_030215
Staining of Integrin α2 (P1E6) at 1ug/ml on frozen normal human kidney tissue.
  • P1E6_Purified_Integrina2b1_Antibody_IHC_030215
    Staining of Integrin α2 (P1E6) at 1ug/ml on frozen normal human kidney tissue.
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910901 100 µL 187.00€
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Description

CD49b is a 170 kD transmembrane protein, also known as α2 integrin, VLA-2 α chain, Integrin α2 and GPIa. It associates with CD29 (β1 integrin) to form VLA-2, a collagen and laminin receptor on many cell types including monocytes, platelets, activated T cells, megakaryocytes, neuronal cells, epithelial cells, and osteoclasts. CD49b has been reported to interact with F-actin and matrix metalloproteinase 1. CD49b is a platelet alloantigen and has been associated with neonatal alloimmune thrombocytopenia. Deficiencies in this protein have been associated with hemorrhagic disorders.

Product Details
Technical Data Sheet (pdf)

Product Details

Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
This monoclonal antibody was generated against human HT1080 fibrosarcoma cells.
Formulation
Phosphate-buffered solution.
Preparation
The antibody was purified by affinity chromatography.
Concentration
1 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C. Please note the storage condition for this antibody has been changed from -20°C to between 2°C and 8°C. You can also check your vial or your CoA to find the most accurate storage condition for this antibody.
Application

IHC-F - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by immunohistochemical staining.

The optimal working dilution should be determined for each specific assay condition.
IHC: 1:1,000

Tissue: Frozen sections
Pretreatment: None
Incubation: 60 minutes at room temperature
 

Application Notes

This antibody is effective in Immunohistochemistry (IHC).

IHC Positive Control: Normal Human Kidney

This antibody is directed against the a2 subunit. It was subsequently purified using protein G.

Application References
  1. Wayner EA, et al. 2007. Meths. Enzymol. In: Integrins. 426:117.
RRID
AB_2565103 (BioLegend Cat. No. 910901)

Antigen Details

Biology Area
Cell Biology, Neuroscience, Signal Transduction, Synaptic Biology
Molecular Family
Adhesion Molecules
Gene ID
3673 View all products for this Gene ID
UniProt
View information about CD49b on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 4    Revision Date: 01/05/2022

For research use only. Not for diagnostic use. Not for resale. BioLegend will not be held responsible for patent infringement or other violations that may occur with the use of our products.

 

*These products may be covered by one or more Limited Use Label Licenses (see the BioLegend Catalog or our website, www.biolegend.com/ordering#license). BioLegend products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products, reverse engineer functionally similar materials, or to provide a service to third parties without written approval of BioLegend. By use of these products you accept the terms and conditions of all applicable Limited Use Label Licenses. Unless otherwise indicated, these products are for research use only and are not intended for human or animal diagnostic, therapeutic or commercial use.

 

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Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

  • Purified anti-CD49b (Integrin α2)

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