- 1H10 (See other available formats)
- Other Names
- MACH, FLICE, Mch5
- Rat IgG2a
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- Product Citations
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Caspase-8 is involved in the apoptosis mediated by CD95 and TNFR-1. It is suggested that following the triggering of apoptosis by CD95 or TNFR-1, the adaptor molecule FADD interact physically with cytosolic caspase-8 and initiate the apoptotic cascade. The active caspase-8 consists of two subunits of p18 and p10. This antibody should recognize the whole length of human caspase-8 and some isofrms of lower MW.Product Details
- Antibody Type
- Host Species
- Full length caspase-8 fusion protein
- This antibody is provided in phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography
- 0.5 mg/ml
- Storage & Handling
- Upon receipt, store between 2°C and 8°C.
WB - Quality tested
IHC, ELISA - Reported in the literature, not verified in house
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. Western blotting, suggested working dilution(s): Use 0.5-1 µg antibody per ml antibody dilution buffer for each mini-gel. It is recommended that the reagent be titrated for optimal performance for each application.
- Application References
- Sanchez I et al. 1999. Neuron. 22:623
- Li H, et al. 1998. Cell 94:491
- Product Citations
AB_2068466 (BioLegend Cat. No. 645501)
- Full length protein of 55kd. Contains two homologous domains of DED (death effector domain) of FADD. The remainder of the protein is similar to the CED-3 subfamily of caspases.
Expressed in multiple isoforms in multiple tissues. Relatively high level in peripheral leucocytes.
- Caspase-8 is involved in apoptosis mediated by CD95 and TNFR-1.
- Biology Area
- Apoptosis/Tumor Suppressors/Cell Death, Cell Biology, Neuroscience
- Antigen References
1. Muzio M et al. 1996. Cell 817-827
2. Cohen GM. 1997. Biochem J 326:1
- Gene ID
- 841 View all products for this Gene ID
- View information about Caspase-8 on UniProt.org
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