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PE anti-mouse CD184 (CXCR4) Recombinant Antibody

Pricing & Availability
Clone
QA16A08 (See other available formats)
Regulatory Status
RUO
Other Names
Fusin, LESTR, Sdf1r, Cmkar4, PB-CKR, PBSF/SDF-1
Isotype
Mouse IgG1, κ
Ave. Rating
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Product Citations
publications
QA16A08_PE_CD184_Antibody_060618
C57BL/6 mouse thymocytes were stained with CD4 APC and CXCR4 (clone QA16A08) PE (left) or Mouse IgG1, κ PE isotype control (right).
  • QA16A08_PE_CD184_Antibody_060618
    C57BL/6 mouse thymocytes were stained with CD4 APC and CXCR4 (clone QA16A08) PE (left) or Mouse IgG1, κ PE isotype control (right).
See PE spectral data
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153805 25 µg 94€
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153806 100 µg 249€
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Description

CD184, also known as CXCR4, is a member of the G protein coupled receptor family that binds CXCL12 (SDF1). CXCR4 and CXCL12 play an important role in immune and inflammatory responses through the regulation of cell migration and growth. CXCR4 plays a crucial role in the pathogenesis of several autoimmune diseases such as atherosclerosis, rheumatoid arthritis, and wound healing. In addition, CXCR4 is the cofactor for fusion and entry of the T cell-tropic form of HIV-1.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Mouse
Antibody Type
Recombinant
Host Species
Mouse
Immunogen
Mouse CXCR4-transfected cells
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.
Concentration
0.2 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Application Notes

This recombinant antibody clone is derived from clone L276F12.

Product Citations
  1. Purvis GSD, et al. 2022. Br J Pharmacol. 179:2754. PubMed
RRID
AB_2734225 (BioLegend Cat. No. 153805)
AB_2734226 (BioLegend Cat. No. 153806)

Antigen Details

Structure
G-protein-coupled seven transmembrane receptor, 39.7 kD
Distribution

T lymphocytes, monocytes, macrophages, tissue-committed stem/progenitor cells (TCSCs), mast cells, vascular smooth muscle cells (VSMCs)

Function
Development of cardiovascular and central nervous system, hematopoiesis, and colonization of BM by fetal liver-derived hematopoietic stem cells (HSCs) during embryogenesis, homing and egress of CD34+ CXCR4+ progenitor cells from bone marrow, and their migration into peripheral tissues. Critical role in homing of cancer cells to specific metastatic sites. Possible role in the ubiquitin proteosome system.
Interaction
Robo -1
Ligand/Receptor
CXCL12 (SDF-1)
Cell Type
Macrophages, Mast cells, Monocytes, T cells
Biology Area
Cell Biology, Immunology, Neuroscience, Neuroscience Cell Markers
Molecular Family
CD Molecules, Cytokine/Chemokine Receptors, GPCR
Antigen References
  1. McDermott DH, et al. 2015. Cell. 160:686
  2. Beck TC, et al. 2014. J Exp Med. 211:2567
  3. Ding BS, et al. 2014. Nature. 505:97
  4. Balabanian K, et al. 2012. Blood. 119:5722
Gene ID
12767 View all products for this Gene ID
UniProt
View information about CD184 on UniProt.org

Related FAQs

What type of PE do you use in your conjugates?
We use R-PE in our conjugates.
Go To Top Version: 1    Revision Date: 06/06/2018

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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