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- Clone
- QA19A13 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- Protectin, H19, 1F-5Ag, HRF20, MACIF, MIRL, P-18
- Isotype
- Mouse IgG2a, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
-
Human peripheral blood lymphocytes were stained with anti-human CD59 recombinant (clone QA19A13) PE (filled histogram) or mouse IgG2a, κ PE isotype control (open histogram).
| Cat # | Size | Price | Quantity Check Availability | Save | ||
|---|---|---|---|---|---|---|
| 376003 | 25 tests | 94€ | ||||
| 376004 | 100 tests | 220€ | ||||
CD59 is a 19-25 kD glycosylphosphatidylinositol (GPI)-anchored glycoprotein also known as protectin, MACIF, and H19. It is broadly expressed on hematopoietic and non-hematopoietic cells. CD59 inhibits the cytolytic activity of complement by binding to C9, inhibiting incorporation into C5b-8, and preventing the terminal steps in complement polymerization of the membrane attack complex. CD59 has also been reported to play a role in T cell activation.
Product DetailsProduct Details
- Verified Reactivity
- Human
- Antibody Type
- Recombinant
- Host Species
- Mouse
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
- Preparation
- The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.
- Concentration
- Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
-
FC - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
- Excitation Laser
-
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
- RRID
-
AB_2892458 (BioLegend Cat. No. 376003)
AB_2892458 (BioLegend Cat. No. 376004)
Antigen Details
- Structure
- Ly6 superfamily, single chain GPI-linked membrane protein, 19-25 kD
- Distribution
-
All cell types
- Function
- Blocks complement-mediated lysis by inhibiting MAC formation
- Ligand/Receptor
- Complement components C8, C9
- Biology Area
- Cell Biology, Costimulatory Molecules, Immunology, Neuroinflammation, Neuroscience
- Molecular Family
- CD Molecules
- Antigen References
-
1. Huang Y, et al. 2006. J. Biol. Chem. 281(37):27398-27404.
- Gene ID
- 966 View all products for this Gene ID
- UniProt
- View information about CD59 on UniProt.org
Related Pages & Pathways
Pathways
Related FAQs
- What type of PE do you use in your conjugates?
- We use R-PE in our conjugates.
Other Formats
View All CD59 Reagents Request Custom Conjugation| Description | Clone | Applications |
|---|---|---|
| Purified anti-human CD59 Recombinant Antibody | QA19A13 | FC |
| PE anti-human CD59 Recombinant Antibody | QA19A13 | FC |
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Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
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Purified anti-human CD59 Recombinant Antibody
Pre-lysed human peripheral blood lymphocytes were stained wi... -
PE anti-human CD59 Recombinant Antibody
Human peripheral blood lymphocytes were stained with anti-hu...
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