- A12 (7D4) (See other available formats)
- Regulatory Status
- Other Names
- SLAM, Signaling Lymphocyte Activation Molecule, IPO-3
- Mouse IgG1, κ
- Ave. Rating
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- Product Citations
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CD150 is a 70-95 kD type I transmembrane glycoprotein also known as SLAM or IPO-3. It is a member of the Ig superfamily. It is expressed on a subset of T cells, B cells, dendritic cells, and endothelial cells. The expression of CD150 is upregulated upon activation. CD150 binds to itself as the ligand to be involved in B cell costimulation, proliferation, immunoglobulin production, and signal transduction.Product Details
- Human, African Green, Baboon, Cynomolgus, Rhesus
- Antibody Type
- Host Species
- Activated human PBMC
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and 0.2% (w/v) BSA (origin USA).
- The antibody was purified by affinity chromatography, and conjugated with FITC under optimal conditions.
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.
- Application Notes
Additional reported applications (for the relevant formats) include: immunohistochemical staining of acetone-fixed frozen tissue sections, immunoprecipitation4, and costimulation1,5 of IFN-gamma production and T cell proliferation. The Ultra-LEAF™ purified antibody (Endotoxin <0.01 EU/µg, Azide-Free, 0.2 µm filtered) is recommended for functional assays (Cat. No. 306317 and 306318).
- Application References
- Garcia V, et al. 2001. J. Immunol. 167:5719. (Costim)
- Vincent S, et al. 2002. J. Virol. 76:6121.
- Cocks B, et al. 1995. Nature 376:260.
- Sayos J, et al. 2001. Blood 97:3867. (IP)
- Aversa G, et al. 1997. J. Immunol. 158:4036. (Costim)
- Spencer M, et al. 2010. Am. J. Physiol Endocrinol Metab. 299:1016. PubMed
- Product Citations
AB_314594 (BioLegend Cat. No. 306306)
- Ig superfamily, type I transmembrane glycoprotein, 70-95 kD
T subset (upregulated after activation), B cells, dendritic cells, endothelial cells
- B cell costimulation, proliferation and Ig production
- CD150 (self ligand)
- Cell Type
- B cells, Dendritic cells, Endothelial cells, T cells, Tregs
- Biology Area
- Costimulatory Molecules, Immunology, Innate Immunity
- Molecular Family
- Adhesion Molecules, CD Molecules
- Antigen References
1. Cocks B, et al. 1995. Nature 376:260.
2. Pinchouk V, et al. 1988. AntiCancer Res. 8:1377.
3. Polacino P, et al. 1996. J. Med. Primatol. 25:201.
4. Punnonen J, et al. 1997. J. Exp. Med. 185:993.
- Gene ID
- 6504 View all products for this Gene ID
- View information about CD150 on UniProt.org
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