- W15097A (See other available formats)
- Regulatory Status
- Other Names
- Histone deacetylase 3, HD3, SMAP45, RPD3-2
- Mouse IgG2b, κ
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- Product Citations
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HDAC3, also known as RPD3-2, HDAC-3, and SMAP45, is a histone deacetylase and is responsible for the deacetylation of lysine residues on core histones and other non-histone substrates. The deacetylation of histones is important for transcriptional regulation, cell cycle progression, and other developmental related functions. HDAC3 represses gene expression by participating in the transcriptional repressor activity of BCL6, by deacetylating H3K27 on enhancer elements. It is also related to participating in transcriptional regulation through binding to YY1, which is a a zinc-finger transcription factor.Product Details
- Human, Mouse
- Antibody Type
- Host Species
- Human HDAC3 recombinant protein (405-424 a.a.) conjugated to KLH.
- This antibody is provided in 50% glycerol in aqueous buffered solutions with preservatives.
- The antibody was purified by affinity chromatography and conjugated with HRP under optimal conditions.
- Lot-specific (please contact technical support for concentration and total µg amount, or use our Lookup tool if you have a lot number.)
- Storage & Handling
- Upon receipt, the antibody solution should be stored undiluted at -20°C, and protected from prolonged exposure to light.
WB - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested dilution is 1:1000-1:10000. The optimal dilution should be determined by titration for each individual assay of interest.
25 µl and 100 µl of Direct-Blot™ HRP antibody can be used for approximately 5 and 20 Western blots, respectively, at the recommended concentration/dilution.
- Application Notes
This clone is not recommended for ChIP (Chromatin Immunoprecipitation) assays (as determined by in-house testing).
AB_2687106 (BioLegend Cat. No. 685205)
- 428 amino acids with a predicted molecular weight of 49 kD. It belongs to the class I histone deacetylase family.
- HDAC3 is a deacetylase responsible for the deacetylation of lysine resides on core histones and other non-histone proteins.
- Forms heterodimer with YY1. Interacts with HDAC7, 9, 10, DACH1, DAXX, BCOR, MJD2A/JHDM3A, NRIP1, PRDM6, and SRY.
- Biology Area
- Cell Biology, Chromatin Remodeling/Epigenetics, Neuroscience, Transcription Factors
- Antigen References
1. Hua G, et al. 2016. Proc Natl Acad Sci USA. 113:E626.
2. Choi HK, et al. 2015. Nat. Commun. 6:8225.
3. Kim WY, et al. 2015. Int. J. Mol. Med. 35(1):202-10.
4. McHugh CA, et al. 2015. Nature 521:232.
5. Sun Z, et al. 2013. Mol. Cell. 52:769.
6. Sun Z, et al. 2012. Nat. Med. 18:934.
- Gene ID
- 8841 View all products for this Gene ID
- View information about HDAC3 on UniProt.org
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