- 1D4B (See other available formats)
- Regulatory Status
- Other Names
- Lysosome-associated membrane glycoprotein 1, lysosomal membrane glycoprotein 1, CD107 antigen-like family member A, lysosome-associated membrane protein 1
- Rat IgG2a, κ
- Ave. Rating
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- Product Citations
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CD107a, also known as Lysosome-Associated Membrane Protein 1 (LAMP-1) or LGP-120, is a 110-140 kD type I membrane glycoprotein. Mature CD107a is heavily glycosylated from a 40 kD core protein. This molecule is located on the luminal side of lysosomes. Upon activation, CD107a is transferred to the cell membrane surface of activated platelets, activated lymphocytes, macrophages, epithelial cells, endothelial cells, and some tumor cells. CD107a has been suggested to play a role in the protection of lysosomal membrane from lysosomal hydrolases which is involved in cell adhesion and regulation of tumor metastasis, and mediates autoimmune disease progression. CD107a is a ligand for galaptin and E-selectin. Surface expression of LAMP-1 has been shown to correlate with CD8+ T cell and NK cell cytotoxicity.Product Details
- Verified Reactivity
- Antibody Type
- Host Species
- This monoclonal antibody was raised against NIH/3T3 mouse embryonic fibroblast tissue culture cell membranes. It has been mapped to the N-terminus of LAMP-1.
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA).
- The antibody was purified by affinity chromatography and conjugated with Brilliant Violet 711™ under optimal conditions.
- 0.2 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.75 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
Brilliant Violet 711™ excites at 405 nm and emits at 711 nm. The bandpass filter 710/50 nm is recommended for detection, although filter optimization may be required depending on other fluorophores used. Be sure to verify that your cytometer configuration and software setup are appropriate for detecting this channel. Refer to your instrument manual or manufacturer for support. Brilliant Violet 711™ is a trademark of Sirigen Group Ltd.
Learn more about Brilliant Violet™.
This product is subject to proprietary rights of Sirigen Inc. and is made and sold under license from Sirigen Inc. The purchase of this product conveys to the buyer a non-transferable right to use the purchased product for research purposes only. This product may not be resold or incorporated in any manner into another product for resale. Any use for therapeutics or diagnostics is strictly prohibited. This product is covered by U.S. Patent(s), pending patent applications and foreign equivalents.
- Product Citations
AB_2783065 (BioLegend Cat. No. 121631)
- LAMP-1 is a 406 amino acid protein with a molecular mass of 44 kD.
- Gene ID
- 16783 View all products for this Gene ID
- View information about CD107a on UniProt.org
Related Pages & Pathways
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PE/Dazzle™ 594 anti-mouse CD107a (LAMP-1)
PE anti-mouse CD107a (LAMP-1)
Purified anti-mouse CD107a (LAMP-1)
Biotin anti-mouse CD107a (LAMP-1)
FITC anti-mouse CD107a (LAMP-1)
Alexa Fluor® 488 anti-mouse CD107a (LAMP-1)
Alexa Fluor® 647 anti-mouse CD107a (LAMP-1)
APC anti-mouse CD107a (LAMP-1)
APC/Cyanine7 anti-mouse CD107a (LAMP-1)
Brilliant Violet 421™ anti-mouse CD107a (LAMP-1)
PE/Cyanine7 anti-mouse CD107a (LAMP-1)
Alexa Fluor® 594 anti-mouse CD107a (LAMP-1)
PerCP/Cyanine5.5 anti-mouse CD107a (LAMP-1)
Alexa Fluor® 700 anti-mouse CD107a (LAMP-1)
Brilliant Violet 510™ anti-mouse CD107a (LAMP-1)
Brilliant Violet 711™ anti-mouse CD107a (LAMP-1)
APC/Fire™ 750 anti-mouse CD107a (LAMP-1)
TotalSeq™-A0905 anti-mouse CD107a (LAMP-1)
TotalSeq™-C0905 anti-mouse CD107a (LAMP-1)
TotalSeq™-B0905 anti-mouse CD107a (LAMP-1)