- p282 (H19) (See other available formats)
- Regulatory Status
- V S006
- Other Names
- Protectin, H19, 1F-5Ag, HRF20, MACIF, MIRL, P-18
- Mouse IgG2a, κ
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- Product Citations
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CD59 is a 19-25 kD glycosylphosphatidylinositol (GPI)-anchored glycoprotein also known as protectin, MACIF, and H19. It is broadly expressed on hematopoietic and non-hematopoietic cells. CD59 inhibits the cytolytic activity of complement by binding to C9, inhibiting incorporation into C5b-8, and preventing the terminal steps in complement polymerization of the membrane attack complex. CD59 has also been reported to play a role in T cell activation.Product Details
- Human, Baboon, Chimpanzee, Cynomolgus, Rhesus
- Antibody Type
- Host Species
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and 0.2% (w/v) BSA (origin USA).
- The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.
- Lot-specific (please contact technical support for concentration and total µg amount, or use our Lookup tool if you have a lot number.)
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.
- Excitation Laser
Red Laser (633 nm)
- Application References
- Schlossman S, et al. Eds. 1995. Leucocyte Typing V. Oxford University Press. New York.
AB_2819929 (BioLegend Cat. No. 304711)
AB_2819930 (BioLegend Cat. No. 304712)
- Ly6 superfamily, single chain GPI-linked membrane protein, 19-25 kD
All cell types
- Blocks complement-mediated lysis by inhibiting MAC formation
- Complement components C8, C9
- Biology Area
- Cell Biology, Immunology, Neuroinflammation, Neuroscience, Costimulatory Molecules
- Molecular Family
- CD Molecules
- Antigen References
1. Davies A, et al. 1993. Immunol. Res. 12:258.
2. Lachmann P. 1991. Immunol. Today 12:312.
3. Liszewski M, et al. 1996. Adv. Immunol. 61:201.
- Gene ID
- 966 View all products for this Gene ID
- View information about CD59 on UniProt.org
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