- P1B5 (See other available formats)
- Regulatory Status
- Other Names
- GAP-B3, GAPB3, ILNEB, MSK18, VCA-2, VL3A, VLA3a, FRP-2, galactoprotein B3, VLA-3 subunit alpha, CD49 antigen-like family member C, antigen identified by monoclonal antibody J143, very late activation protein 3 receptor, alpha-3 subunit
Covance Catalog# MMS-490R
- Mouse IgG1, κ
- Ave. Rating
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- Product Citations
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CD49c is a 150 kD α integrin chain known as α3 integrin or VLA-3 α chain. It is a type I transmembrane glycoprotein which is proteolytically cleaved into two disulfide linked fragments of 125 kD and 30 kD. CD49c forms a heterodimer with integrin β1 (α3β1, CD49c/CD29, VLA-3) and is expressed by many types of adhesion cells, such as endothelial cells, epithelial cells, and dermal fibroblasts. Weak expression has been reported on leukocytes. VLA-3 plays a role in cell-cell and cell-matrix adhesion through binding Kalinin, collagen, laminin-1, laminin-5, entactin, and fibronectin.Product Details
- Antibody Type
- Host Species
- The P1B5 monoclonal antibody was generated against human HT1080 cells.
- The concentration is not quantified as this product is sold as undiluted crude mouse ascites fluid. The concentration might vary from lot-to-lot and an estimated concentration would be 1-3 mg/ml.
- Storage & Handling
- Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody. For long-term storage, keep the antibody at -80°C.
IHC-F - Quality tested
FC - Verified
IP - Reported in the literature, not verified in house
- Recommended Usage
Each lot of this antibody is quality control tested by immunohistochemical staining on frozen tissue sections. For immunohistochemistry, a dilution range of 1:250 - 1:500 is suggested. For flow cytometric staining, the suggested dilution of this reagent is between 1:250 - 1:500. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
This antibody recognizes the a3 subunit.
- Application References
- Wayner EA, et al. 2007. Meths. Enzymol. In: Integrins. 426:117.
- Wayner EA, et al. 1993. J Cell Biol. 121:1141. (IP)
- Carter WG, et al. 1990. J Cell Biol. 110:1387. (IP)
- Wayner EA, Carter WG. 1987. J Cell Biol. 105:1873. (IP)
- Product Citations
AB_2565403 (BioLegend Cat. No. 921601)
- CD49c is a 150 kD type I transmembrane glycoprotein
Cellular distribution: Plasma membrane.
Tissue distribution: Endothelial cells, epithelial cells, and dermal fibroblast.
- Biology Area
- Cell Biology, Neuroscience, Signal Transduction, Synaptic Biology
- Molecular Family
- Adhesion Molecules
- Gene ID
- 3675 View all products for this Gene ID
- View information about CD49C on UniProt.org
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