Highlighted relevant publications from Professor El-Agnaf Laboratory
The laboratory has explored the potential use of α-Synuclein as a biomarker for PD. They generated and characterized several novel conformation-specific antibodies for α-Synuclein including clone Syn-O2. They utilized various methods to validate the specificity of this clone in recognizing the oligomeric forms of α-Synuclein. For example, using immunohistochemical studies, they demonstrated staining of Lewy bodies and Lewy neurites with Syn-O2 in tissues derived from PD patients. They then developed a highly specific ELISA assay to quantify α-Synuclein species in biological samples from PD patients and aged-matched healthy controls using clone Syn-O2. Read more in the articles below:
Vaikath NN, et al. 2015. Neurobiol Dis. 79:81 (PubMed)
Majbour NK, et al. 2016. Mol Neurodegener. 11:7 (PubMed)
Learn more about Parkinson’s disease and associated proteins.