- QA17A10 (See other available formats)
- Other Names
- Inducible Costimulator, AILIM, CVID1, CRP1
- Human IgG1, κ
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- Product Citations
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CD278, also know as ICOS, is a type I transmembrane protein, member of the CD28/CTLA-4 family, present in the cell surface as an homodimer of 47-57 kD. ICOS is expressed in activated T cells where it has a pivotal role in T cell activation, proliferation and Th1/Th2 differentiation and the antibody response; its ligand is CD275.Product Details
- Human, Mouse, Rat
- Antibody Type
- Host Species
- Mouse T cell clone D10.G4.1
- 0.2 µm filtered in phosphate-buffered solution, pH 7.2, containing no preservative. Endotoxin level is <0.01 EU/µg of the protein (<0.001 ng/µg of the protein) as determined by the LAL test.
- The Ultra-LEAF™ (Low Endotoxin, Azide-Free) antibody was purified by affinity chromatography.
- 1.0 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C. This Ultra-LEAF™ solution contains no preservative; handle under aseptic conditions.
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Type I transmembrane protein, member of the CD28/CTLA-4 family, homodimer of 47-57 kD.
Activated T cells
- Pivotal role in T cell activation, proliferation and Th1/Th2 differentiation; required for humoral immune response.
- B7-H2 (ICOS-L, CD275)
- Cell Type
- T cells, Th17, Thymocytes, Tregs
- Biology Area
- Immunology, Costimulatory Molecules
- Molecular Family
- CD Molecules
- Antigen References
- Tahiliani V, et al. 2017. J Immunol. 198:218.
- Pedros C, et al. 2016. Nat Immunol 17:1005.
- Maazi H, et al. 2015. Immunity 42:538.
- Guedan S, et al. 2014. Blood. 124:1070.
- Weber JP, et al. 2015. J. Exp. Med. 212:217.
- Gene ID
- 29851 View all products for this Gene ID
- View information about CD278 on UniProt.org
- Does BioLegend test each LEAF™ antibody by functional assay?
No, BioLegend does not test LEAF™ antibodies by functional assays unless otherwise indicated. Due to the possible complexities and variations of uses of biofunctional antibodies in different assays and because of the large product portfolio, BioLegend does not currently perform functional assays as a routine QC for the antibodies. However, we do provide references in which the antibodies were used for functional assays and we do perform QC to verify the specificity and quality of the antibody based on our strict specification criteria.
- Do you guarantee that your antibodies are totally pathogen free?
BioLegend does not test for pathogens in-house aside from the GoInVivo™ product line. However, upon request, this can be tested on a custom basis with an outside, independent laboratory.
- Does BioLegend test each LEAF™ antibody for potential pathogens?
No, BioLegend does not test for pathogens in-house unless otherwise indicated. However, we can recommend an outside vendor to perform this testing as needed.
- Have you tested this LEAF™/Ultra-LEAF™ antibody for in vivo or in vitro applications?
We don't test our antibodies for in vivo or in vitro applications unless otherwise indicated. Depending on the product, the TDS may describe literature supporting usage of a particular product for bioassay. It may be best to further consult the literature to find clone specific information.
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