- BL28556 (See other available formats)
- Other Names
- Protein Wnt-3a
- Mouse IgG2b, κ
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- Product Citations
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Wnt3a, one of Wnt family members, plays a key role in carcinogenesis. Studies have shown that Wnt3a can both promote and suppress cancer progression depending on the cancer type. Mechanistically, Wnt3a activates downstream signaling pathways in a canonical manner by binding to its receptor Frizzled (Fz) and co-receptor lipoprotein receptor-related proteins 5/6 (LRP5/6), which ultimately promote nuclear translocation of the transcription factor b-catenin. Wnt3A is also involved in non-oncogenic pathways. It modulates brain-derived insulin by increasing NeuroD1 expression levels. Following traumatic brain injury, Wnt3A secreted by mesenchymal stem cell was shown to be neuroprotective and promote neurocognitive recovery.Product Details
- Antibody Type
- Host Species
- 0.01 M PBS, pH 7.4, containing 0.02% NaN3, 50% glycerol.
- The antibody was purified by affinity chromatography.
- 0.5 mg/ml
- Storage & Handling
- Store at 4°C for up to 3 months. For longer term storage aliquot into small volumes and store at -20°C.
WB - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.2 - 1.0 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.
- Wnt3A has 2 isoforms. Isoform 1 is a 352 amino acid protein with a molecular mass of ~40 kD. Isoform 2 is a 385 amino acid protein with a molecular mass of ~43 kD.
Tissue Distribution: Lung, placenta, carcinoma tissues (breast cancer, colon cancer, gastric cancer, leukemia, and liver cancer).
Cellular distribution: Plasma membrane, cytosol, and extracellular.
- Wnt3a plays crucial role in carcinogenesis of various tissue types.
- Wnt3a binds to its receptor Frizzled (Fz) and co-receptor lipoprotein receptor-related proteins 5/6 (LRP5/6), and activates the canonical Wnt signaling pathway.
- Ligand Receptor
- Receptor: Frizzled (Fz); Coreceptor: Lipoprotein receptor-related proteins LRP5/6
- Biology Area
- Neuroscience, Synaptic Biology
- Antigen References
- Lu, C. et al. 2017. Int. J. Oncol. 51(4):1135-1145.
- He, S. et al. 2015. Chin. J. Cancer. 34(12):554-62.
- Chen D, et al. 2014. Int J Clin Exp Pathol. 7(4), 1359–1368.
- Gene ID
- 89780 View all products for this Gene ID
- View information about Wnt3A on UniProt.org
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