- Poly28645 (See other available formats)
- Other Names
- VASN, Protein slit-like 2, Slit2
- Rabbit Polyclonal IgG
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- Product Citations
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Vasorin is a typical type-I membrane protein and is expressed in multiple physiological and pathological conditions. In vascular smooth muscle cells, vasorin functions as a TGF-β binding protein and modulates the arterial response after injury. In the brain, vasorin expression is induced by the HIF1α/STAT3 coactivator complex under hypoxia conditions. Induced vasorin binds to and regulates membrane Notch1 turnover and maintains the glioma-stem-like cells in the hypoxic niche.Product Details
- Human, Mouse, Rat
- Antibody Type
- Host Species
- Recombinant human Vasorin protein (Asn298-Gly539) expressed in E. coli.
- 0.01 M PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
- The antibody was purified by affinity chromatography.
- 0.5 mg/ml
- Storage & Handling
- Store at 4°C for up to 3 months. For longer term storage aliquot into small volumes and store at -20°C.
WB - Quality tested
IHC-P - Validated
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.5 - 2.0 µg per ml. For immunohistochemistry, a concentration range of 5.0 - 10 µg/ml is suggested. It is recommended that the reagent be titrated for optimal performance for each application.
- Human vasorin is a 673 amino acid protein with a predicted molecular mass of 72 kD.
Tissue distribution: Aorta, kidney, placenta, brain, heart, liver, lung, and skeletal muscle
Cellular distribution: Secreted and membrane
- Varosin is an inhibitor of TGF-β signaling and responds to hypoxia-induced stress.
- Varosin interacts with TGF-β and Notch-1.
- Cell Type
- Neurons, Oligodendrocytes
- Biology Area
- Cell Biology, Neuroscience, Stem Cells
- Antigen References
- Man J. et al. 2018. Cell Stem Cell. 22(1):104-118.e6.
- Ikeda Y. et al. 2004. Proc Natl Acad Sci U S A. 101(29):10732-7.
- Gene ID
- 114990 View all products for this Gene ID
- View information about Vasorin on UniProt.org
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