- O92A4 (See other available formats)
- Regulatory Status
- Other Names
- Tollip, Toll Interacting Protein
- Mouse IgG1, κ
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- Product Citations
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Tollip, also known as Toll interacting protein, is a ubiquitin-binding protein and an inhibitory adaptor protein involved in IL-1 and Toll-like receptor (TLR) signaling pathway. Alterations in Tollip gene expression levels has been linked to tuberculosis and idiopathic pulmonary fibrosis, suggesting a role for Tollip in innate immune system. Tollip has also been reported to mediate autophagic clearance of poly-ubiquitinated proteins.Product Details
- Antibody Type
- Host Species
- Full length human recombinant Tollip (NP_061882) produced in HEK293T cell.
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
WB - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 1.0 - 5.0 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
This clone is highly specific to human Tollip. It does not cross react with murine Tollip.
- Product Citations
AB_2750411 (BioLegend Cat. No. 854401)
AB_2750472 (BioLegend Cat. No. 854402)
- Tollip is a 274 amino acid protein with an apparent molecular mass of ~30 kD.
Tissue Distribution: Ubiquitously expressed.
Cellular Distribution: Plasma membrane, extracellular, cytosol, lysosome, and nucleus.
- Tollip is a component of the IL-1 and TLR signaling pathway involved in innate immune response.
- Tollip has been reported to interact with TOM1, TLR2, TLR4, IRAK1, IR-1RI, TOM1L2, and ILRAP.
- Biology Area
- Cell Biology, Immunology, Innate Immunity, Neurodegeneration, Neuroscience, Protein Trafficking and Clearance
- Molecular Family
- Enzymes and Regulators
- Antigen References
- Capelluto DG. 2012. Microbes Infect. 14(2): 140
- Brandao I, et al. 2015. Gut Microbes. 6(3):202
- Gene ID
- 54472 View all products for this Gene ID
- View information about Tollip on UniProt.org
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