- 4H2-D5-E9 (See other available formats)
- Other Names
- Transducin Beta Like 1 X-Linked, F-Box-Like/WD Repeat-Containing Protein TBL1X, SMAP55, EBI
- Mouse IgG2b, κ
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- Product Citations
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TBL1 is a protein that has sequence similarity with WD40 repeat-containing protein family. TBL1 plays an essential role in signal transduction, gene regulation, vesicle trafficking, and cytoskeletal arrangement through protein-protein interactions. TBL1 is also found as a component of nuclear receptor corepressor complexes through interaction with histone deacetylase 3, and is involved in Notch signaling. It is associated with diseases including ocular albinism and atrial septal defect 4.Product Details
- Human, Mouse, Rat
- Antibody Type
- Host Species
- Purified recombinant human TBL1 protein fragments expressed in E.coli.
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography.
- 0.5 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
WB - Quality tested
IHC-P - Validated
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 1.0 - 2.0 µg/mL. For immunohistochemistry on formalin-fixed paraffin-embedded tissue sections, a concentration range of 5.0 - 10 µg/mL is suggested. It is recommended that the reagent be titrated for optimal performance for each application.
- TBL1 is a 577 amino acid protein with a predicted and observed molecular mass of ~62 kD.
Tissue Distribution: Brain, kidney, liver, heart, and lung
Cellular Distribution: Nucleus
- TBL1 is involved in the regulation of gene expression, RNA processing, vesicle trafficking, and cytoskeleton assembly.
- HDAC3, Notch1
- Cell Type
- Biology Area
- Cell Biology, Neurodegeneration, Neuroscience, Signal Transduction
- Molecular Family
- Cytoskeletal Proteins, Nuclear Markers
- Antigen References
- Perissi V, et al. 2004. Cell. 116(4):511-26.
- Li J, et al. 2008. Nat Cell Biol. 10(2):160-9.
- Gene ID
- 6907 View all products for this Gene ID 21372 View all products for this Gene ID 302711 View all products for this Gene ID
- View information about TBL1 on UniProt.org
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