- Sp3G11/1 (See other available formats)
- Other Names
- Spastic paraplegia 4 protein, SPG4, ADPSP, FSP2
- Mouse IgG2a, κ
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- Product Citations
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Spastin is a microtubule-severing protein that cleaves longer microtubules (MTs) to shorter ones. The severing of MT regulates its numbers and mobility, and the distribution of the plus-end. This has also been related to membrane trafficking of microtubules. Mutations in the spastin gene SPG4 is the main cause for hereditary spastic paraplegia, a neurodegenerative disorder mainly occurring in corticospinal tracks. Due to the presence of 2 start codons in SPG4 gene, 2 isoforms of spastin exist: a 68 kD isoform termed M1 and a 60 kD isoform termed M87. The M1 isoform is only detected in the adult spinal cord while the M87 isoform is ubiquitously expressed.Product Details
- Human, Mouse, Rat
- Antibody Type
- Host Species
- Recombinant human spastin protein
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
WB - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 5.0 - 10 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.
- Human spastin is a 616 amino acid protein with a predicted molecular mass of 67 kD.
Tissue distribution: Expressed in brain, heart, kidney, liver, lung, pancreas, placenta, and skeletal muscle. The short isoform may predominate in the brain and spinal cord.
Cellular distribution: Cytoskeleton, endoplasmic reticulum, nucleus, and membrane.
- Spastin is involved in the regulation of microtubule severing.
- Spastin mostly forms homohexamer.
- Cell Type
- Biology Area
- Cell Biology, Cell Motility/Cytoskeleton/Structure, Neurodegeneration, Neuroscience
- Molecular Family
- Cytoskeletal Proteins
- Antigen References
- Hazan J. et al. 1999. Nat Genet. 23(3):296-303.
- Solowska JM. et al. 2014. J Neurosci. 34(5):1856-67.
- Gene ID
- 6683 View all products for this Gene ID
- View information about Spastin on UniProt.org
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