Purified anti-REEP1 Antibody

Pricing & Availability
Clone
N345/51 (See other available formats)
Other Names
Receptor Accessory Protein 1, Spastic Paraplegia 31 Protein, C2orf2, SPG31, Receptor Expression-Enhancing Protein 1, Chromosome 2 Open Reading Frame 23, HMN5B, Yip2a
Isotype
Mouse IgG2b, κ
Ave. Rating
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Product Citations
publications
N345-51_Purified_REEP1_Antibody_1_112018
Western blot of purified anti-REEP1 antibody (clone N345/51). Lane 1: Molecular weight marker; Lane 2: 40 µg of human brain lysate; Lane 3: 20 µg of mouse brain lysate; Lane 4: 20 µg of rat brain lysate. The blot was incubated with 1 µg /mL of the primary antibody overnight at 4°C, followed by incubation with HRP-labeled goat anti-mouse IgG (Cat. No. 405306). Enhanced chemiluminescence was used as the detection system.
  • N345-51_Purified_REEP1_Antibody_1_112018
    Western blot of purified anti-REEP1 antibody (clone N345/51). Lane 1: Molecular weight marker; Lane 2: 40 µg of human brain lysate; Lane 3: 20 µg of mouse brain lysate; Lane 4: 20 µg of rat brain lysate. The blot was incubated with 1 µg /mL of the primary antibody overnight at 4°C, followed by incubation with HRP-labeled goat anti-mouse IgG (Cat. No. 405306). Enhanced chemiluminescence was used as the detection system.
Cat # Size Price Quantity Avail. Save
857901 25 µg £47
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857902 100 µg £94
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Description

Receptor expression enhancing protein 1 (REEP1) is a multi-pass mitochondrion membrane protein that is part of the DP1 family. REEP1 has been reported to interact and enhance the cell surface expression of odorant receptors.  Interestingly, REEP1 mutations have been linked to neurodegenerative disorders of upper and lower motor neurons, hereditary spastic paraplegia (HSP), and distal hereditary motor neuropathy type V (dHMN-V) (1).

Product Details
Technical Data Sheet (pdf)

Product Details

Reactivity
Human, Mouse, Rat
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
Mouse recombinant protein fragment corresponding to amino acids 111-201.
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

WB - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 1.0 - 5.0 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.

Antigen Details

Structure
REEP1 is a 201 amino acid protein with a molecular mass of ~22 kD.
Distribution

Tissue Distribution: Cerebellum, smooth muscle, stomach, colon, and testis.
Cellular distribution: Endoplasmic reticulum, mitochondrion, and plasma membrane.

Function
REEP1 is required for endoplasmic reticulum formation, shaping and remodeling by linking endoplasmic reticulum tubules to the cytoskeleton. REEP1 may also enhance the cell surface expression of odorant receptors.
Interaction
REEP1 interacts with SPAST, ALT1, microtubules, odorant receptors, and ZFYVE27.
Biology Area
Cell Biology, Mitochondrial Function, Neuroscience
Antigen References
  1. Carl M Hurt, et al. 2014. Brain Res. 2014 1545: 12–22
  2. Pengli Zheng, et al. 2018. Cell Res. 28(8): 833–854.
  3. Lavie J, et al. 2017. Hum Mol Genet. 15;26(4):674-685.
  4. Youngshin Lim, et al. 2015. Ann Neurol. 78(5): 679–696.
Gene ID
65055 View all products for this Gene ID
UniProt
View information about REEP1 on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 1    Revision Date: 11/21/2018

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