- W18116A (See other available formats)
- Other Names
- RB Transcriptional Corepressor 1, Retinoblastoma-Associated Protein, Protein Phosphate 1, Regulatory Subunit 130
- Rat IgG2a, κ
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- Product Citations
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Rb is a key regulator of the cell cycle, more specifically during the transition from the G1 to S phases. The underphosphorylated, active form of Rb interacts directly with E2F1, leading to cell cycle arrest, while the hyperphosphorylated form decouples from E2F1, thus promoting the transcription of genes promoting entry into the S phase. Rb is directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation.Product Details
- Antibody Type
- Host Species
- Partial recombinant human Rb protein.
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography.
- 0.5 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
WB - Quality tested
IP, ICC - Validated
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.2 µg/mL. For immunoprecipitation, the suggested use of this reagent is 2.5 µg/mL. For immunocytochemistry, a concentration of 5 μg/mL is recommended. It is recommended that the reagent be titrated for optimal performance for each application.
- Rb is a 928 amino-acid protein with a predicted molecular weight of 110 kD.
Localized to the nucleoplasm/Ubiquitously expressed.
- Regulator; tumor suppressor; chromatin stability
- E2F1 Transcription Factor
- Biology Area
- Apoptosis/Tumor Suppressors/Cell Death, Cell Cycle/DNA Replication
- Molecular Family
- Tumor Suppressors
- Antigen References
- Dunham A, et al. 2004. Nature. 428(6982):522-8.
- Hogg A, et al. 1992. Oncogene. (7):1445-51.
- Cho HS, et al. 2012. Neoplasia. 14(6):476-86.
- Mori T, et al. 2011. Cell Cycle. 10(19):3284-99.
- Rose JE, et al. 2010. Mol Med. 16(7-8):247-53.
- Gene ID
- 5925 View all products for this Gene ID
- View information about Rb on UniProt.org
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