- OX-47 (See other available formats)
- Regulatory Status
- Other Names
- OX-47, CE-9
- Mouse IgG1, κ
- Ave. Rating
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- Product Citations
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CD147 is a 54 kD type I integral transmembrane protein, also called extracellular metalloproteinase inducer (EMMMPRIN) or M6 in humans, Basigin or gp42 in mouse, and OX-47 or CE-9 in rat. It is a heavily glycosylated Ig superfamily member and is expressed widely in hematopoietic and non-hematopoietic tissues. CD147 is an adhesion molecule and, through interaction with integrins, plays an important role in fetal, neuronal, blood cells and extracellular matrix development.Product Details
- Antibody Type
- Host Species
- T blasts from a mixed lymphocyte reaction
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
FC - Quality tested
IHC-F, WB - Reported in the literature, not verified in house
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
Additional reported applications (for the relevant formats) include: immunohistochemical staining of acetone-fixed frozen sections1 and Western blotting2.
(PubMed link indicates BioLegend citation)
- Glenn M, et al. 1995. Circulation 92:1919. (IHC)
- Betsuyaku T, et al. 2003. Am. J. Respir. Cell Mol. Biol. 28:600. (WB)
- Product Citations
AB_1186183 (BioLegend Cat. No. 204601)
- Single chain type I transmembrane 58 kd heavily glycosylated protein. N terminal extracellular part consists of two C2 type Ig-like domains which are highly glycosylated. Recently reported: isoform with an additional membrane-distal Ig-like domain.
CD147 is expressed at varying levels in many cells types, including haematopoietic, epithelial, and endothelial cells. Expressed on immature thymocytes and at varying levels on spleen cells , bone marrow cells and macrophages.
- CD147 is implicated in multiple functions, such as matrix metalloproteinase induction, cell adhesion, retinal cell development, HIV attachment, embryonic development and T cell activation.
- Biology Area
- Molecular Family
- Adhesion Molecules, CD Molecules
- Antigen References
1. Glenn M, et al. 1995. Circulation 92:1919.
2. Betsuyaku T, et al. 2003. Am. J. Respir. Cell Mol. Biol. 28:600.
- Gene ID
- 25246 View all products for this Gene ID
- View information about CD147 on UniProt.org
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