- O91F10 (See other available formats)
- Other Names
- PPT1, Palmitoyl-Protein Thioesterase 1
- Mouse IgG1, κ
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PPT1 (Palmitoyl-protein thioesterase-1) was originally discovered as the enzyme that catalyzes polypeptide depalmitoylation. During lysosomal degradation, PPT1 removes the thioester-linked palmitic acid from the modified cysteine of targeted protein, which is important to palmitoylated protein degradation. Deficits in PPT1 have been identified as the leading cause of infantile neuronal ceroid liposuscinosis. Recent research has also linked PPT1 to Huntington Disease, Alzheimer disease, Schizophrenia, and mental retardation, as S-palmitoylation has been found to affect synaptic regulation by regulating AMPA receptors trafficking and function.Product Details
- Antibody Type
- Host Species
- Recombinant protein corresponding to amino acids 100-306 of human PPT1.
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
WB - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 1.0 - 5.0 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.
AB_2783442 (BioLegend Cat. No. 855801)
AB_2783443 (BioLegend Cat. No. 855802)
- PPT1 is a 306 amino acid protein with an apparent molecular mass of ~34 kD.
Tissue Distribution: Ubiquitously expressed.
Cellular Distribution: Extracellular, nucleus, lysosome, golgi apparatus, and cytosol.
- PPT1 is involved in protein depalmitoylation and lysosomal degradation of palmitoylated protein.
- PPT1 interacts with CLN5, ATP5F1A, and ATP5F1B.
- Biology Area
- Cell Biology, Neurodegeneration, Neuroscience, Protein Trafficking and Clearance, Synaptic Biology
- Molecular Family
- Presynaptic proteins
- Antigen References
- Han J, et al. 2015. Acta. Pharm. Sin. B. 5:1-7.
- Hawkins-Salsbury JA, et al. 2013. Biochim. Biophys. Acta. 11:1906-9.
- Young FB, et al. 2012. Prog. Neurobiol. 97:220.
- Gene ID
- 5538 View all products for this Gene ID
- View information about PPT1 on UniProt.org
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