- P87F12H6 (See other available formats)
- Other Names
- PPM1A, Protein Phosphatase 1A, Protein Phosphatase 2C, Alpha isoform, Protein Phosphatase, Mg2+/Mn2+ Dependent 1A
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Protein Phosphatase 2Cα (PP2C-α) is a ubiquitously expressed magnesium- and manganese-dependent enzyme with a broad specificity of target substrates. It functions by dephosphorylating serine/threonine residues on its target proteins, and has been shown to regulate SMAD, PP2C-α, MAPK, p38 and JNK kinase signaling pathways. PP2C-α deficiency is associated with pancreatic and prostate cancers.Product Details
- Antibody Type
- Host Species
- Partial recombinant human PPC2-α protein corresponding to amino acid residues 202-382.
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
WB - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.1 - 1.0 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
When tested for western blot application, this clone produced a non-specific band of roughly ~48 kD in certain cell lines.
- PP2C-α is a 382 amino acid protein with a predicted molecular weight of 42.4 kD.
Cytosolic distribution/ubiquitously expressed.
- Biology Area
- DNA Repair/Replication, Signal Transduction
- Molecular Family
- Protein Kinases/Phosphatase
- Antigen References
- Schilling SH, et al. 2006. Cell. 125:838.
- Lin X, et al. 2006. Cell. 125:915.
- Chau JF, et al. 2012. Nat. Commun. 3:836.
- Gene ID
- 5494 View all products for this Gene ID
- View information about PP2C-alpha on UniProt.org
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