- 8A11-C11-C9 (See other available formats)
- Other Names
- ALPP, PLAA, , Placental Alkaline Phosphatase 1
- Mouse IgG1, κ
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- Product Citations
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PLAP is a membrane-bound glycosylated dimeric enzyme that was initially identified in the placenta. PLAP is also known as phospholipase A2 activating protein. Abnormal amyloid beta-induced activation of synaptic phospholipase A2 results in synaptic degeneration due to elevated levels of platelet-activating factor, suggesting that PLAP may be a contributing factor in synaptic damage observed in Alzheimer’s disease patients. Clinically, PLAP is broadly used as a tumor marker, especially in geminoma, seminoma, and ovarian cancer.Product Details
- Antibody Type
- Host Species
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
IHC-P - Quality tested
WB - Validated
- Recommended Usage
Each lot of this antibody is quality control tested by formalin-fixed paraffin-embedded immunohistochemical staining. For immunohistochemistry, a concentration range of 2.0 - 10 µg/ml is suggested. For Western blotting, the suggested use of this reagent is 0.5 - 10 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.
- PLAP is a 795 amino acid protein with predicted molecular mass of ~87 kD and observed molecular mass of ~70 kD.
Tissue Distribution: Ubiquitously expressed
Cellular Distribution: Plasma membrane
- Phospholipase A2 activating protein that may be involved in amyloid beta-induced synaptic degeneration.
- Ubiquitin, UBXN6, VCP, YOD1
- Cell Type
- Astrocytes, Endothelial cells, Neurons
- Biology Area
- Cancer Biomarkers, Neurodegeneration, Neuroscience, Synaptic Biology
- Molecular Family
- Protein Kinases/Phosphatase
- Antigen References
- Watanabe S et al., 2012. Pediatr Neurosurg. 48(3):141
- Bate C et al., 2010. Mol Neurodegener. 5:13
- Huynh ML et al., 2011. Genesis. 49(11):851
- Gene ID
- 18786 View all products for this Gene ID
- View information about PLAP on UniProt.org
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