- Poly28610 (See other available formats)
- Other Names
- PRDX6, peroxiredoxin VI, Peroxiredoxin-6, AOP2, Antioxidant protein 2
- Rabbit Polyclonal IgG
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Human peroxiredoxin 6 is encoded by the PRDX6 gene and belongs to one of six peroxiredoxin families including PRDX1, PRDX2, PRDX3, PRDX4, PRDX5, and PRDX6. Peroxiredoxins are expressed ubiquitously and serve as thiol-specific antioxidant enzymes that regulate the redox state, and reduce H2O2 and lipid peroxides. Peroxiredoxin 6 interacts with saitohin (STH) which is nested within the intron 9 of the Tau gene demonstrates similar protein expression pattern as Tau protein. This interaction combined with abnormal expression of peroxiredoxin 6 may be a contributing factor to several neurodegenerative diseases including Alzheimer’s and Pick’s diseases. In Alzheimer's disease, peroxiredoxin 6 is upregulated in reactive astrocytes which are found colocalized with amyloid-beta (Aβ) peptide-positive diffuse plaques. This upregulation is believed to reduce oxidative stress caused by Aβ neurotoxicity.Product Details
- Antibody Type
- Host Species
- Recombinant human PRDX6 (amino acid sequence Met1~Pro224)
- 0.01 M PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
- The antibody was purified by affinity chromatography.
- 0.5 mg/ml
- Storage & Handling
- Store at 4°C for up to 3 months. For longer term storage aliquot into small volumes and store at -20°C.
WB - Quality tested
IHC-P - Validated
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.1 - 0.5 µg per ml. For immunohistochemistry on formalin-fixed paraffin-embedded tissue sections, a concentration range of 0.1 - 0.5 µg/ml is suggested. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
This antibody also detects peroxiredoxin 6 dimers in the liver lysate.
AB_2814585 (BioLegend Cat. No. 861001)
- Peroxiredoxin 6 is a 224 amino acid protein with predicted and observed molecular mass of ~25 kD.
Tissue Distribution: Predominantly expressed in the lung, brain, liver, and testis
Cellular Distribution: Nucleus, cytosol, extracellular, lysosome, and plasma membrane
- Peroxiredoxin 6 is involved in redox regulation and protects cells against lipid peroxidation.
- Peroxiredoxin 6 forms homodimer and heterodimer, and interacts with GSTP1, APEX1, and STH.
- Cell Type
- Astrocytes, Mature Neurons, Neurons
- Biology Area
- Apoptosis/Tumor Suppressors/Cell Death, Neurodegeneration, Neuroinflammation, Neuroscience, Signal Transduction
- Molecular Family
- APP/Aβ Degradation, Enzymes and Regulators, Lysosomal Markers
- Antigen References
- Manevich Y, et al. 2014. Free Radic Biol Med. 72: 210.
- Zhou S, et al. 2016. Free Radic Biol Med. 94:145.
- Power JH, et al. 2008. Acta Neuropathol. 115:611.
- Gene ID
- 9588 View all products for this Gene ID
- View information about Peroxiredoxin 6 on UniProt.org
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