- Poly6190 (See other available formats)
- Regulatory Status
- Other Names
- p63, δN p63-α, -β, -γ
- Rabbit Polyclonal IgG
- Ave. Rating
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- Product Citations
|Cat #||Size||Price||Quantity Check Availability||Save|
|619001||50 µl (5 Western blots)||£86.00|
|619002||200 µl (20 Western blots)||£239.00|
p63 (ΔN) is a member of the p53 family. This protein has multiple isoforms TA p63-α, -β, γ, ΔN p63-α, -β, and -γ. The molecular weights of the p63 isoforms α=66 kD, β=52 kD, and γ=45 kD. This nuclear protein is essential for limb formation, epidermal morphogenesis, and epithelial stem cell regeneration. ΔN isoforms are antagonistic to p53; TA isoforms can transactivate p53 targets. The p63 ΔN isoforms repress TA isoforms; mutant p53 abrogates p63 transactivation. This protein interacts with p53, p73, and the various TA- and ΔN isoforms. The Poly6190 antibody recognizes human p63 ΔN isoforms and has been shown to be useful for Western blotting.Product Details
- Human (recognizes ΔN-isoforms)
- Antibody Type
- Host Species
- Modified peptide
- This antibody is provided in phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and 50% glycerol.
- The antibody was purified by antigen-affinity chromatography.
- Lot-specific (please contact technical support for concentration and total µg amount, or use our Lookup tool if you have a lot number.)
- Storage & Handling
- Upon receipt, store frozen at -20°C.
WB - Quality tested
IHC - Reported in the literature, not verified in house
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. Western blotting, suggested working dilution(s): Use 10 µl per 5 ml antibody dilution buffer for each mini-gel. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
This product may contain other non-IgG subtypes.
(PubMed link indicates BioLegend citation)
- Medawar A, et al. 2008. PLoS ONE 3:e3441. PubMed
- Di Girolamo N, et al. 2009. Transplantation. 87:1571. PubMed
- Bray LJ, et al. 2012. Biomaterials. 33:3529. PubMed
- Zhou Y, et al. 2011. Clin. Invest. Med. 34:E184. (IHC)
- Stewart RM, et al. 2015. Invest Ophthalmol Vis Sci. 56:2021. PubMed
- Curtis KM, et al. 2015. PLoS One. 10:123642. PubMed
- Ahronian LG, et al. 2015. PLoS One.10:123816. PubMed
- Product Citations
AB_2256361 (BioLegend Cat. No. 619001)
AB_2207170 (BioLegend Cat. No. 619002)
- p53 family, six isoforms, ΔN p63α, β, γ, approximately 66 kD, 52 kD, 45 kD
- Essential for limb formation, epidermal morphogenesis, epithelial stem cell regeneration. ΔN isoforms antagonistic to p53; TA isoforms can transactivate p53 targets
- p53, p73, TA- and ΔN isoforms
- Biology Area
- Apoptosis/Tumor Suppressors/Cell Death, Cell Biology, Cell Cycle/DNA Replication, Transcription Factors
- Antigen References
1. Yang A, et al. 1998. Mol Cell. 2:305.
2. Celli J, et al. 1999. Cell. 99:143.
3. Gaiddon C, et al. 2001. Mol Cell Biol. 21:1874.
4. Benard J, et al. 2003. Hum Mutat. 21:182.
- ΔN isoforms repress TA isoforms, mutant p53 abrogates p63 transactivation
- Gene ID
- 8626 View all products for this Gene ID
- View information about p63 on UniProt.org
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