Purified anti-mouse TCR Vγ1.1 + Vγ1.2 Antibody

Pricing & Availability
Clone
4B2.9 (See other available formats)
Other Names
Vγ1 and Vγ2 (Tonegawa nomenclature)
Isotype
Armenian hamster IgG
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Product Citations
publications
4B2.9_PE_1_112311
C57BL/6 mouse splenocytes were stained with TCR Vγ1.1 + Vγ1.2 (clone 4B2.9) PE (top) or Armenian hamster IgG PE isotype control (bottom).
  • 4B2.9_PE_1_112311
    C57BL/6 mouse splenocytes were stained with TCR Vγ1.1 + Vγ1.2 (clone 4B2.9) PE (top) or Armenian hamster IgG PE isotype control (bottom).
  • 4B2.9_PE_2_112311
Cat # Size Price Quantity Avail. Save
142702 100 µg £120
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Description

In mice, the TCR g locus consists of seven Vg, four Jg and four Cg genes, which are differentially expressed through their lifespan. During fetal and early postnatal life, very few γ/δ T cells express TCR Vγ1.1 or Vγ1.2 chains. In adult mice, however, a major fraction of the γ/δ T cell repertoire comprise either TCR Vγ1.1 or Vγ1.2 chains. The Vγ1.1 gene rearranges almost exclusively with the Jg4-Cg4 genes, while the Vγ1.2 gene preferentially does with Jg1.

Product Details
Technical Data Sheet (pdf)

Product Details

Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Armenian Hamster
Immunogen
TCR Vγ1.1/Vδ6 T3.13.1 hybridoma
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Application Notes

mAb 4B2.9 specifically recognizes γ/δ T cells expressing Vγ1.1 and/or Vγ1.2 chains.

Application References

(PubMed link indicates BioLegend citation)
  1. Pereira P and Boucontet L. 2004. J. Immunol. 173:3261. (FC)
RRID
AB_10960122 (BioLegend Cat. No. 142702)

Antigen Details

Distribution
Subset of γ/δ T cells
Function
Antigen recognition
Cell Type
T cells
Biology Area
Immunology, Adaptive Immunity
Molecular Family
TCRs
Antigen References

1. Garcia-Herrera A, et al. 2011. Am. J. Surg. Pathol. 35:1214.
2. Gutierrez A, et al. 2010. J. Clin. Oncol. 28:3816.
3. Zhang X, et al. 2009. Hematology 14:237.

Gene ID
110067 View all products for this Gene ID
UniProt
View information about TCR Vg1.1 + Vg1.2 on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 1    Revision Date: 11/30/2012

For research use only. Not for diagnostic use. Not for resale. BioLegend will not be held responsible for patent infringement or other violations that may occur with the use of our products.

 

*These products may be covered by one or more Limited Use Label Licenses (see the BioLegend Catalog or our website, www.biolegend.com/ordering#license). BioLegend products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products, reverse engineer functionally similar materials, or to provide a service to third parties without written approval of BioLegend. By use of these products you accept the terms and conditions of all applicable Limited Use Label Licenses. Unless otherwise indicated, these products are for research use only and are not intended for human or animal diagnostic, therapeutic or commercial use.

 

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Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
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