- 1B3.3 (See other available formats)
- Regulatory Status
- Other Names
- Tib, TCRB, TCRbeta
- Armenian Hamster IgG
- Ave. Rating
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- Product Citations
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The TCR Vβ8 family consists of three members, namely Vβ8.1, 8.2 and 8.3. 1B3.3 reacts with Vβ8.3 only, but not Vβ8.1 or Vβ8.2. Most mouse strains have about 20% Vβ8+ T cells in the periphery. However, C57BR, C57L, SJL, SWR (Tcra haplotype) and RIII strains (Tcrc haplotype) do not express Vβ8 due to a gene deletion at the Vβ8 loci. Exogenous superantigen, such as staphylococcal enterotoxin B, stimulates lymphocytes bearing Vβ8 and selectively eliminate those T cells in vivo.Product Details
- Antibody Type
- Host Species
- Armenian Hamster
- 3.L2 T Cell Clone Expressing the vβ8.3 TCR
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
Clone 1B3.3 recognizes TCR vß8.3 from both C57BL/6 and BALB/c strains.
(PubMed link indicates BioLegend citation)
- Kersh G, et al. 1998. J. Immunol. 161:585.
AB_2750428 (BioLegend Cat. No. 156302)
- Ig super family; TCR is an 85-kd hetero-dimer composed of alpha and beta chain.
Expressed in a subset of αβ T cells
- Recognition of Peptide/MHC, T cell activation
- Peptide/MHC complex
- Cell Targets
- Cell Type
- T cells
- Biology Area
- Adaptive Immunity, Immunology
- Molecular Family
- Antigen References
- Haskins K, et al. 1984. J. Exp. Med. 160:452
- Davis MM, et al. 1998. Annu Rev Immunol. 16:523
- Kersh GJ, et al. 1998. J Immunol. 161:585.
- Tomonari K. 1996. Immunogenetics. 44:73
- Gene ID
- 21577 View all products for this Gene ID
- View information about TCR vbeta8.3 on UniProt.org
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