- Eat-2 (See other available formats)
- Regulatory Status
- Other Names
- Armenian Hamster IgG
- Ave. Rating
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- Product Citations
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CD81 is a 26 kD non-glycosylated member of the tetraspanin superfamily (TM4SF), also known as TAPA-1. CD81 is expressed on T and B cells, NK cells, dendritic cells, thymocytes, endothelial cells, and fibroblasts. CD81 induces B cell adhesion via the VLA-4 integrin and has been shown to play a role in early T cell development. CD81 associates with several other cell-surface proteins in a multimolecular complex, including CD19, CD21, CD20, CD37, CD53, and CD82 in B cells, and CD4, CD8 and CD82 in T cells.Product Details
- Mouse, Rat
- Antibody Type
- Host Species
- Armenian Hamster
- CD81+ mouse B lymphoma 38C13
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
FC - Quality tested
IP, WB - Reported in the literature, not verified in house
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per 106 cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
The Eat-2 antibody reacts with mouse and rat CD81. Additional reported applications (for the relevant formats) include: immunoprecipitation1,2, Western blotting1,2, induction of homotypic adhesion of B lymphocytes1, stimulation of B cells undergo early apoptotic events1, and promotion of T cell motility2.
(PubMed link indicates BioLegend citation)
- Product Citations
AB_313136 (BioLegend Cat. No. 104901)
AB_313137 (BioLegend Cat. No. 104902)
- TM4SF tetraspanin, 26 kD
T cells and B cells, NK cells, dendritic cells, thymocytes, endothelial cells, fibroblasts
- Regulates cell growth
- Cell Type
- B cells, Dendritic cells, Endothelial cells, Fibroblasts, NK cells, T cells, Thymocytes
- Biology Area
- Molecular Family
- Adhesion Molecules, CD Molecules
- Antigen References
1. Barclay AN, et al. 1997. The Leukocyte Antigen FactsBook Academic Press.
2. Levy S, et al. 1998. Annu. Rev. Immunol. 16:89.
3. Maeker HT, et al. 1997. FASEB J. 11:428.
4. Boismenu R, et al. 1996. Science 271:198.
- Gene ID
- 12520 View all products for this Gene ID 25621 View all products for this Gene ID
- View information about CD81 on UniProt.org
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