- HMN3-133 (See other available formats)
- Regulatory Status
- Other Names
- Neurogenic locus notch homolog protein 3, Notch-3, CADASIL
- Armenian Hamster IgG
- Ave. Rating
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- Product Citations
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The Notch receptors are highly conserved from invertebrates to mammals.While Notch1 and Notch 2 exhibit the highest structural similarity among the four mammalian Notch receptors. Notch 3 has a number of structural and functional differences.The binding of Notch 3 to its ligands results in the proteolysis of Notch and movement of intracellular portions of Notch into the nucleus.This translocation triggers a series of signaling process.Notch 3 is primarily expressed in adult arterial smooth muscle cells.Notch 3 gene mutation can cause CADASIL, an inherited early stroke syndrome.Product Details
- Antibody Type
- Host Species
- Armenian Hamster
- Notch 3-Fc fusion protein
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
FC - Quality tested
IHC-F - Reported in the literature, not verified in house
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
(PubMed link indicates BioLegend citation)
- Product Citations
AB_1227735 (BioLegend Cat. No. 130502)
- Transmembrane receptor, heterodimer consisting of a C-terminal fragment and N-terminal fragment probably linked by disulphide bonds. Contains 5 ankyrin repeats, 29-36 EGF repeats, 3 Notch/Lin repeats.
Notch 3 is primarily expressed in vascular smooth muscle cells, also found in proliferating neuroepithelium.
- Critical role in the structural integrity of distal resistance artieries. Mutations in the Notch 3 receptor on vascular smooth muscles cells is associated with an inherited neurodegenerative disease CADASIL (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopthy)
- Jag1,2; Delta 1,2
- Cell Type
- Epithelial cells
- Biology Area
- Antigen References
1. Ehebauer ME, et al. 2006. Biochem J 392:13
2. Shimizu K, et al. 2000. Mol Cell Biology 20:18
3. Tanigaki K, et al. 2007. Nature Immunol 8:451
4. Bellavia D, et al. 2008. 27:5092
5. Louvi A, et al. Dev Neurosci. 2006. 28:5
- Gene ID
- 18131 View all products for this Gene ID
- View information about Notch 3 on UniProt.org
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