- 35B (See other available formats)
- Regulatory Status
- Other Names
- Rat IgG1, κ
- Ave. Rating
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- Product Citations
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IL-25 (IL-17E) is a member of the IL-17 family of proinflammatory cytokines which include at least six members including IL-17A (IL-17), IL-17B, IL-17C, IL-17D, IL-17E (also called IL-25), and IL-17F. IL-17E is found at low levels in various peripheral tissues. It is a proinflammatory cytokine that promotes airway eosinophilia in mice. IL-17E plays a role in Th2 type inflammatory diseases, such as asthma and atopic dermatitis.Product Details
- Antibody Type
- Host Species
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
ELISA - Quality tested
Neut - Reported in the literature, not verified in house
- Recommended Usage
Each lot of this antibody is quality control tested by ELISA assay. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
Neutralization: The Ultra-LEAF™ purified antibody (Endotoxin <0.01 EU/µg, Azide-Free, 0.2 µm filtered) is recommended for neutralization of mouse IL-25 bioactivity (Cat. No. 514417).
(PubMed link indicates BioLegend citation)
- Angkasekwinai P, et al. 2007. J. Exp Med. 204:1509.
AB_2043954 (BioLegend Cat. No. 514401)
- Cytokine; 19 kD
- Induce proinflammatory responses, promote the expression of the prototypical Th2 genes
- Cell Sources
- Activated Th2 cells, bone marrow-derived mast cells, and alveolar macrophages
- Cell Targets
- IL-17RB mRNA transcripts are abundantly expressed in the kidney and liver and at lower levels in the testes, brain, small intestine, and other organs.
- IL-17BR (EVI27, IL17Rh1)
- Biology Area
- Apoptosis/Tumor Suppressors/Cell Death, Cell Biology, Immunology, Innate Immunity, Signal Transduction
- Molecular Family
- Antigen References
1. Fort MM, et al. 2001. Immunity 15:985.
2. Lee J, et al. 2001. J. Biol Chem. 276:1660.
3. Hurst SD, et al. 2002. J. Immunol. 169:443.
4. Kleinschel MA, et al. 2007. J. Exp. Med. 204:161.
- Gene ID
- 140806 View all products for this Gene ID
- View information about IL-25 on UniProt.org
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